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公开(公告)号：US20210041418A1
公开(公告)日：2021-02-11
申请号：US17083589
申请日：2020-10-29
Applicant: Agilent Technologies, Inc.
Inventor： Xiaobo Wang , Yama A. Abassi , Nan Li , Lincoln Muir , Xiao Xu
IPC: G01N33/50 , G01N33/543 , G01N27/02
Abstract: Methods of assessing cytolysis of cancer cells are provided, which include: providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, adding target cells characterized as cancer cells to a well of the device adding effector cells to the well to form a test well, where the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance-based curves over time.
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公开(公告)号：US12066428B2
公开(公告)日：2024-08-20
申请号：US17083589
申请日：2020-10-29
Applicant: Agilent Technologies, Inc.
Inventor： Xiaobo Wang , Yama A. Abassi , Nan Li , Lincoln Muir , Xiao Xu
CPC classification number: G01N33/5011 , C12N1/06 , C12N5/0693 , C12N7/00 , G01N27/021 , G01N33/5047 , C12N1/38
Abstract: Methods of assessing cytolysis of cancer cells are provided, which include: providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, adding target cells characterized as cancer cells to a well of the device adding effector cells to the well to form a test well, where the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance-based curves over time.
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