公开(公告)号：US20250073071A1

公开(公告)日：2025-03-06

申请号：US18815973

申请日：2024-08-27

Applicant: Alcon Inc.

Inventor： Gangjun LIU ,  Lingfeng YU

IPC: A61F9/007 ,  A61F9/008

Abstract: A system and method for corneal cross-linking with real-time monitoring are provided. The method comprises determining a plurality of measurement locations in a region of a cornea, and applying a corneal cross-linking treatment to the region of the cornea. During the application of the corneal cross-linking treatment, the method also comprises acquiring a temporal OCT interferogram at each OCT measurement location, generating temporal complex OCT data based on the temporal OCT interferogram, determining biomechanical data based on the temporal complex OCT data, and adjusting the corneal cross-linking treatment based on the biomechanical data.

公开(公告)号：US20250072747A1

公开(公告)日：2025-03-06

申请号：US18805430

申请日：2024-08-14

Applicant: Alcon Inc.

Inventor： Gangjun LIU ,  Lingfeng YU

IPC: A61B3/10

Abstract: An optical coherence tomography (OCT) scanning system for measuring ocular tissue characteristics of a patient's eye. The system includes an OCT scanner configured to implement a scanning sequence on the ocular tissue that scans the ocular tissue with an optical signal to obtain OCT data based on a reflected version of the optical signal. The system includes a computer with a processor configured to provide control signals to the OCT scanner to implement the scanning sequence, and to determine a rate of change of the phase or amplitude data associated with the scans. The system determines a growth constant of the reflected version of the optical signal based on the rate of change of the phase or amplitude data, and determines, based on the growth constant, a diffusion coefficient associated with the cornea. The system determines, based on the diffusion coefficient, a quantitative parameter of the cornea.

公开(公告)号：US20250082231A1

公开(公告)日：2025-03-13

申请号：US18825865

申请日：2024-09-05

Applicant: Alcon Inc.

Inventor： Gangjun LIU ,  Lingfeng YU

IPC: A61B5/11 ,  A61B3/10

Abstract: Certain aspects of the present disclosure provide systems and methods for measuring eye-tissue biomechanics via blink stimulation. In certain embodiments, a method may be performed by a computer in communication with an optical coherence tomography (OCT) device. The method includes monitoring movement relative to an eye of a patient via one or more images from a camera. The method also includes detecting a blink of the eye of the patient responsive to the monitoring. The method also includes, responsive to the detected blink, recording data resultant from a scan, by the OCT device, of at least a portion of a tissue of the eye. The method also includes measuring a tissue response to the detected blink based on the recorded data from the scan.

公开(公告)号：US20250073062A1

公开(公告)日：2025-03-06

申请号：US18805420

申请日：2024-08-14

Applicant: Alcon Inc.

Inventor： Gangjun LIU ,  Lingfeng YU ,  Yilin ZHAO

IPC: A61F9/00 ,  A61B3/10

Abstract: Described herein include a system and method for a device for drug delivery and ophthalmic diagnostics designed to assist in the diagnosis of the physical state of a cornea through the projection of droplets onto the eye. In some embodiments, the apparatus includes a liquid sampling unit, an electric droplet generator, and a steering unit. In some embodiments, the liquid sampling unit is configured to project a quantity of liquid, while the electric droplet generator receives the quantity of liquid and outputs one or more electrically charged droplets. The steering unit uses electrostatic forces to steer the electrically charged droplets along a trajectory onto the cornea of the patient's eye.

公开(公告)号：US20250072749A1

公开(公告)日：2025-03-06

申请号：US18816959

申请日：2024-08-27

Applicant: Alcon Inc.

Inventor： Gangjun LIU ,  Lingfeng YU ,  Yilin ZHAO

IPC: A61B3/10 ,  A61B3/00 ,  A61F9/008

Abstract: Certain aspects of the present disclosure provide systems and methods for measuring biomechanics in real-time at multiple eye-tissue locations. In certain embodiments, a method may be performed by a computer in communication with an optical coherence tomography (OCT) device. The method includes receiving an indication of a stimulus applied to eye tissue of a patient. The method also includes instructing the OCT device to emit a plurality of beams, at approximately the same time, to a plurality of measurement locations on the eye tissue in response to the received indication. The method also includes receiving, from the OCT device, OCT data for each of the plurality of measurement locations. The method also includes measuring tissue responses to the stimulus at the plurality of measurement locations based on the OCT data.

公开(公告)号：US20250072748A1

公开(公告)日：2025-03-06

申请号：US18815135

申请日：2024-08-26

Applicant: Alcon Inc.

Inventor： Gangjun LIU ,  Lingfeng YU

IPC: A61B3/10 ,  A61B5/00

Abstract: Systems and methods for measuring corneal biomechanical properties are provided. In certain embodiments, a method comprises determining a plurality of optical coherence tomography (OCT) measurement locations in a region of a cornea; for each OCT measurement location: applying a mechanical excitation to the cornea at the OCT measurement location, and measuring a response of the cornea to the mechanical excitation by acquiring temporal OCT data at the OCT measurement location; generating temporal deformation data for the region of the cornea based on the temporal OCT data at each OCT measurement location; and generating biomechanical data for the region of the cornea based on the temporal deformation data.