-
公开(公告)号：US20230330441A1
公开(公告)日：2023-10-19
申请号：US18214386
申请日：2023-06-26
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING
IPC: A61N7/00 , A61F7/00 , B06B1/02 , A61K9/00 , A61K41/00 , A61P35/00 , B06B1/06 , A61K31/197 , A61F7/02 , A61B18/00 , A61B17/32 , A61B17/00
CPC classification number: A61N7/00 , A61F7/0085 , B06B1/0207 , A61K9/0053 , A61K41/0033 , A61K41/0061 , A61P35/00 , B06B1/0622 , A61K31/197 , A61N2007/006 , B06B2201/76 , A61F2007/0288 , A61B2018/00023 , A61N2007/0078 , A61F2007/0056 , A61B2018/00446 , A61N2007/0095 , A61N2007/0073 , A61F2007/0096 , A61B2017/320069 , A61N2007/003 , A61N2007/0082 , A61B2017/00084
Abstract: Disclosed are methods of producing randomized ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
-
公开(公告)号：US20230226379A1
公开(公告)日：2023-07-20
申请号：US18125971
申请日：2023-03-24
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING
CPC classification number: A61N7/00 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , A61F7/0085 , B06B1/0207 , B06B1/0622 , A61B2017/00084
Abstract: Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.
-
公开(公告)号：US20240293683A1
公开(公告)日：2024-09-05
申请号：US18656122
申请日：2024-05-06
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING
IPC: A61N7/00 , A61B17/00 , A61B17/32 , A61B18/00 , A61F7/00 , A61F7/02 , A61K9/00 , A61K31/197 , A61K41/00 , A61M21/00 , A61M21/02 , A61P35/00 , B06B1/02 , B06B1/06
CPC classification number: A61N7/00 , A61F7/0085 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61M21/02 , A61P35/00 , B06B1/0207 , B06B1/0622 , A61B2017/00084 , A61B2017/320069 , A61B2018/00023 , A61B2018/00446 , A61F2007/0056 , A61F2007/0096 , A61F2007/0288 , A61M2021/0027 , A61M2021/005 , A61N2007/003 , A61N2007/006 , A61N2007/0073 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , B06B2201/76
Abstract: Disclosed are systems and methods of producing ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
-
公开(公告)号：US20240108917A1
公开(公告)日：2024-04-04
申请号：US18540651
申请日：2023-12-14
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING
CPC classification number: A61N7/00 , A61F7/0085 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , B06B1/0207 , B06B1/0622 , A61B2017/00084
Abstract: Methods of treating tumors by administering compounds to a patient are provided. Compounds such as drugs, may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate as compounds such as a protoporphyrin compound in tumor cells. After such accumulation, such compounds are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.
-
公开(公告)号：US20240024649A1
公开(公告)日：2024-01-25
申请号：US18040610
申请日：2021-08-04
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING , John BALLARD , Gregg MILLER
CPC classification number: A61M37/0092 , A61N7/00 , B06B1/0215 , B06B1/0625 , A61N2007/0086 , B06B2201/55 , B06B2201/76
Abstract: Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.
-
Patent Agency Ranking
公开(公告)号：US20210370103A1
公开(公告)日：2021-12-02
申请号：US17400011
申请日：2021-08-11
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING
Abstract: Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves that do not converge and do not diverge. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
-
公开(公告)号：US20240278041A1
公开(公告)日：2024-08-22
申请号：US18648807
申请日：2024-04-29
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING
IPC: A61N7/00 , A61B17/00 , A61B17/32 , A61B18/00 , A61F7/00 , A61F7/02 , A61K9/00 , A61K31/197 , A61K41/00 , A61M21/00 , A61M21/02 , A61P35/00 , B06B1/02 , B06B1/06
CPC classification number: A61N7/00 , A61F7/0085 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61M21/02 , A61P35/00 , B06B1/0207 , B06B1/0622 , A61B2017/00084 , A61B2017/320069 , A61B2018/00023 , A61B2018/00446 , A61F2007/0056 , A61F2007/0096 , A61F2007/0288 , A61M2021/0027 , A61M2021/005 , A61N2007/003 , A61N2007/006 , A61N2007/0073 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , B06B2201/76
Abstract: Disclosed are methods of using planar or defocused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
-
公开(公告)号：US20240207652A1
公开(公告)日：2024-06-27
申请号：US18411849
申请日：2024-01-12
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING
IPC: A61N7/00 , A61B17/00 , A61B17/32 , A61B18/00 , A61F7/00 , A61F7/02 , A61K9/00 , A61K31/197 , A61K41/00 , A61P35/00 , B06B1/02 , B06B1/06
CPC classification number: A61N7/00 , A61F7/0085 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , B06B1/0207 , B06B1/0622 , A61B2017/00084 , A61B2017/320069 , A61B2018/00023 , A61B2018/00446 , A61F2007/0056 , A61F2007/0096 , A61F2007/0288 , A61N2007/003 , A61N2007/006 , A61N2007/0073 , A61N2007/0078 , A61N2007/0082 , A61N2007/0095 , B06B2201/76
Abstract: Disclosed are methods of producing ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
-
公开(公告)号：US20230338754A1
公开(公告)日：2023-10-26
申请号：US18215515
申请日：2023-06-28
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING , John BALLARD , Gregg MILLER
CPC classification number: A61N7/00 , A61K41/0033 , B06B1/0629 , B06B1/0633 , A61N2007/0043 , A61N2007/0078 , B06B2201/76
Abstract: Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.
-
10.发明公开公开(公告)号：US20230338751A1
公开(公告)日：2023-10-26
申请号：US18214371
申请日：2023-06-26
Applicant: Alpheus Medical, Inc.
Inventor： Vijay AGARWAL , Braden ELIASON , Jeremy LING
CPC classification number: A61N7/00 , A61K9/0053 , A61K31/197 , A61K41/0033 , A61K41/0061 , A61P35/00 , A61F7/0085 , B06B1/0207 , B06B1/0622 , A61B2017/00084
Abstract: Disclosed are methods of using planar or defocused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.
-
-
-
-
-
-
-
-
-
Search Results
21
records
(took 0.016 seconds)
