公开(公告)号：US20200038354A1

公开(公告)日：2020-02-06

申请号：US16516597

申请日：2019-07-19

Applicant: Aston University

Inventor： Asif AHMED ,  Keqing WANG ,  Shakil AHMAD

IPC: A61K31/198 ,  G01N33/68

Abstract: The invention provides a method of diagnosis or prognosis of preeclampsia in a pregnant subject, comprising providing a sample from a pregnant subject and measuring the ratio between the amount of (a) one or both of sFlt-1 and PlGF, and (b) one or both of a breakdown product of heme and a breakdown product of arginine, in the sample. Also described are assay kits and a computer adapted for use in the method. Also described is a method of treating preeclampsia, comprising administering a pharmaceutically effective amount of L-arginine and/or citrulline and an inhibitor of arginase or pharmaceutically acceptable salts thereof. Also described is a method of treating cancer, comprising treating a subject with a therapeutically effective amount of an anti-VEGF compound, L-arginine and an arginase inhibitor.

公开(公告)号：US20220000821A1

公开(公告)日：2022-01-06

申请号：US17348942

申请日：2021-06-16

Applicant: Aston University

Inventor： Asif AHMED ,  Keqing WANG ,  Shakil AHMAD

IPC: A61K31/198 ,  G01N33/68

Abstract: Described is a method of diagnosis or prognosis of preeclampsia in a pregnant subject, comprising providing a sample from a pregnant subject and measuring the ratio between the amount of (a) one or both of sFlt-1 and PlGF, and (b) one or both of a breakdown product of heme and a breakdown product of arginine, in the sample. Also described are assay kits and a computer adapted for use in the method. Also described is a method of treating preeclampsia, comprising administering a pharmaceutically effective amount of L-arginine and/or citrulline and an inhibitor of arginase or pharmaceutically acceptable salts thereof. Also described is a method of treating cancer, comprising treating a subject with a therapeutically effective amount of an anti-VEGF compound, L-arginine and an arginase inhibitor.

公开(公告)号：US20180036271A1

公开(公告)日：2018-02-08

申请号：US15551468

申请日：2016-02-18

Applicant: Aston University

Inventor： Asif AHMED ,  Keqing WANG ,  Shakil AHMAD

IPC: A61K31/198

CPC classification number: A61K31/198 ,  G01N33/689 ,  G01N2800/368 ,  A61K2300/00

Abstract: Described is a method of diagnosis or prognosis of preeclampsia in a pregnant subject, comprising providing a sample from a pregnant subject and measuring the ratio between the amount of (a) one or both of sFlt-1 and PlGF, and (b) one or both of a breakdown product of heme and a breakdown product of arginine, in the sample. Also described are assay kits and a computer adapted for use in the method. Also described is a method of treating preeclampsia, comprising administering a pharmaceutically effective amount of L-arginine and/or citrulline and an inhibitor of arginase or pharmaceutically acceptable salts thereof. Also described is a method of treating cancer, comprising treating a subject with a therapeutically effective amount of an anti-VEGF compound, L-arginine and an arginase inhibitor.