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公开(公告)号：US09744240B2
公开(公告)日：2017-08-29
申请号：US14036445
申请日：2013-09-25
Applicant: BASF SE
Inventor： Felicitas Guth , Karl Kolter , Michael Schönherr , Franz Weber
Abstract: A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble Vitamin E-derivative and at least one hydrophilic polymer. In one embodiment the storage-stable dust-free homogeneous particle formulation, consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives, with the proviso, that the sum of (a), (b), (c) and (d) equals 100% by weight of the formulation, and wherein the fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Methods of making the particulate formulation by a spray granulation process are also provided.
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公开(公告)号：US20250127899A1
公开(公告)日：2025-04-24
申请号：US18727863
申请日：2023-02-03
Applicant: BASF SE
Inventor： Lukas Ries , Thorsten Cech , Elisabeth Gruenstein , Felicitas Guth , Karl Kolter
Abstract: The present invention relates to a powder mixture for the preparation of a granulate comprising as constituent at least a filler or at least an active ingredient or both and as granulation aid potassium sodium tartrate tetrahydrate (PST). Optionally constituents of the powder mixture to be granulated are binders, disintegrants and further customary auxiliaries. It was an object of the present invention to provide a powder mixture which can be granulated without adding a liquid but where the water for the granulation is released in-situ from PST. An additional drying step is not required.
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公开(公告)号：US20250017861A1
公开(公告)日：2025-01-16
申请号：US18714342
申请日：2022-11-30
Applicant: BASF SE
Inventor： Silke Gebert , Felicitas Guth , Claudia Scholten , Thorsten Cech , Florian Bang
IPC: A61K9/16
Abstract: The present invention relates to a direct tableting auxiliary composition based on lactose powder mixed intimately with a water-soluble polyethylene glycol-polyvinyl alcohol graft copolymeras binder, a lubricants, a colorant and optionally a crosslinked insoluble polyvinylpyrrolidone as tablet disintegrating agent.
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公开(公告)号：US20200010618A1
公开(公告)日：2020-01-09
申请号：US16481566
申请日：2018-01-30
Applicant: BASF SE
Inventor： Hartwig Voss , Felicitas Guth , Emiel Jan Kappert , Pedro Sa Gomes
Abstract: Process for providing purified polyether block copolymers comprising polyoxyethylene (PEO) and polyoxypropylene (PPO) moieties wherein the purified product is obtained by an ultrafiltration step of a solution of the polyether block copolymers and wherein the block copolymers are depleted in lower molecular impurities.
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公开(公告)号：US20230257501A1
公开(公告)日：2023-08-17
申请号：US18014508
申请日：2021-07-02
Applicant: BASF SE
Inventor： Theo Smit , Ferdinand Paul Brandl , Felicitas Guth , Karl Kolter , Frank Schmidt
IPC: C08F226/10 , C08F2/06 , A61K9/16
CPC classification number: C08F226/10 , C08F2/06 , A61K9/1635
Abstract: Copolymer, wherein structural units are derived from: i) an acrylic carboxylic acid monomer (4 to 18% by weight), selected from the group consisting of acrylic acid and methacrylic acid, ii) a 5 hydrophobic methacrylate (more than 8% by weight), selected from a group consisting of isopropyl methacrylate, tert-butyl methacrylate and cyclohexyl methacrylate, iii) a N-vinyl lactam, selected from a group consisting of N-vinyl pyrrolidone and N-vinylcaprolactam and optionally iv) 2-hydroxyethyl methacrylate, with the proviso that the total amount of structural units derived from the monomer groups adds up to 100% by weight, and the calculated solubility parameter SP of 10 the copolymer is between 22.0 and 25.0 MPa1/2, and the use of the copolymers as crystallization inhibitors in pharmaceutical dosage forms for inhibiting the recrystallization of an active ingredient in an aqueous environment of a human or animal body.
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Patent Agency Ranking
公开(公告)号：US11154508B2
公开(公告)日：2021-10-26
申请号：US16624332
申请日：2018-06-05
Applicant: BASF SE
Inventor： Bernhard Fussnegger , Silke Gebert , Felicitas Guth , Karl Kolter
Abstract: A finely divided binder in powder form consisting of a polyethylene glycol-polyvinyl alcohol graft polymer particles, wherein the particles have an average particle size D[4,3] in the range of from 10 to 70 μm.
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公开(公告)号：US20210163879A1
公开(公告)日：2021-06-03
申请号：US16772865
申请日：2018-12-07
Applicant: BASF SE
Inventor： Felicitas Guth , Karl Kolter , Nigel A. Langley , Kerri Gaumer Freidl , Kristina Brueggemann
IPC: C12N5/00
Abstract: A method for stabilizing cells in cell culture production, the method comprising culturing a cell line capable of expressing proteins in cell culture media, and supplementing said cell culture media with a graft polymer in which N-vinyl caprolactam and vinyl acetate moieties are grafted on a polyethylene glycol backbone.
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公开(公告)号：US20210069112A1
公开(公告)日：2021-03-11
申请号：US16772273
申请日：2018-12-07
Applicant: BASF SE
Inventor： Ferdinand Paul Brandl , Theo Smit , Felicitas Guth , Karl Kolter , Maximilian Angel , Frank Schmidt
IPC: A61K9/16 , C08F220/18 , A61K47/32 , A61K31/635 , A61K31/58 , A61K31/216 , A61K31/5377
Abstract: Terpolymer, wherein 20 to 35% by weight of the structural units are derived from acrylic acid, 45 to 60% by weight of the structural units from a hydrophobic methacrylate selected from a group consisting of isopropyl methacrylate, tert-butyl methacrylate and cyclohexyl methacrylate and 15 to 40% by weight of the structural units from a third olefinic monomer selected from the group consisting of N-vinyl lactam, hydroxy ethyl methacrylate and phenoxyethyl acrylate with the proviso that the total amount of structural units derived from the three monomer groups adds up to 100% by weight, and the use of the terpolymers as crystallization inhibitors in pharmaceutical dosage forms for inhibiting the recrystallization in an aqueous environment of a human or animal body of an active ingredient.
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公开(公告)号：US20250090464A1
公开(公告)日：2025-03-20
申请号：US18727804
申请日：2023-02-03
Applicant: BASF SE
Inventor： Lukas Ries , Thorsten Cech , Elesabeth Gruenstein , Felicitas Guth , Karl Kolter
IPC: A61K9/16
Abstract: The present invention relates to a powder mixture for the preparation of a granulate comprising as constituent at least a filler or at least an active ingredient or both and as granulation aid Magnesium diacetate×4H2O and/or Magnesium dichloride×6H2O and/or Magnesium sulfate×7H2O and/or Disodium sulfate xH2O and/or Sodium thiosulfate×5H2O and/or Na3PO4×12H2O and/or Na2HPO4×12H2O/7H2O and/or Sodium acetate×3H2O. Optionally constituents of the powder mixture to be granulated are binders, disintegrants and further customary auxiliaries. It was an object of the present invention to provide a powder mixture which can be granulated without adding a liquid but where the water for the granulation is released in-situ from Magnesium diacetate×4H2O and/or Magnesium dichloride×6H2O and/or Magnesium sulfate×7H2O and/or Disodium sulfate xH2O and/or Sodium thiosulfate×5H2O and/or Na3PO4×12H2O and/or Na2HPO4×12H2O/7H2O and/or Sodium acetate×3H2O. An additional drying step is not required.
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公开(公告)号：US20240350414A1
公开(公告)日：2024-10-24
申请号：US18684728
申请日：2022-08-19
Applicant: BASF SE
Inventor： Silke Gebert , Felicitas Guth , Thorsten Cech , Karl Kolter
IPC: A61K9/20 , A61K31/192 , A61K31/451
CPC classification number: A61K9/2031 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K31/192 , A61K31/451
Abstract: The present invention relates to a direct tableting auxiliary composition based on lactose powder mixed intimately with a water-soluble polyethylene glycol-polyvinyl alcohol graft copolymeras binder, crosslinked insoluble polyvinylpyrrolidone as tablet disintegrating agent and a lubricant.
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