公开(公告)号：US3765841A

公开(公告)日：1973-10-16

申请号：US3765841D

申请日：1971-08-06

Applicant: BECKMAN INSTRUMENTS INC

Inventor： PAULSON G ,  RAY R

IPC: G01N27/06 ,  C12M1/34 ,  G01N27/26 ,  G01N33/487 ,  G01N33/62 ,  C12K1/10 ,  G01N33/16

CPC classification number: G01N27/3271 ,  Y10T436/171538

Abstract: A method and apparatus for determining the concentration of a component in a sample, i.e. the concentration of urea in biological fluids, such as blood serum, wherein the sample, upon being introduced into solution with a reagent, reacts therewith, causing a continuing change in a characteristic of the solution, and wherein the rate of the reaction is indicative of the concentration of the component in the sample. A sensor is provided for monitoring the characteristic of the solution and for generating a first electrical output signal proportional thereto. Differentiator circuit means are provided for producing a second electrical signal proportional to the time derivative of the first signal, the time derivative signal being indicative of the concentration of the component in the sample.

Abstract translation: 用于确定样品中组分浓度的方法和装置，即生物流体如血清中的尿素浓度，其中样品在被试剂引入溶液中与其反应时，导致持续变化 溶液的特征，并且其中反应速率指示样品中组分的浓度。 提供传感器用于监测溶液的特性并产生与其成比例的第一电输出信号。 提供微分电路装置用于产生与第一信号的时间导数成比例的第二电信号，时间导数信号表示样品中组分的浓度。