公开(公告)号：US20210387972A1

公开(公告)日：2021-12-16

申请号：US17283301

申请日：2019-10-15

Applicant: BIOGEN MA INC.

Inventor： Fengmei ZHENG ,  Anton PETERSON ,  Kalyan VASUDEVAN ,  Chaomin LI ,  Daniel B. PATIENCE ,  Yiqing LIN

IPC: C07D405/14

Abstract: Provided are crystalline forms of (R)-1-(tert-butyl)-N-(8-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-2-(oxetan-3-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-5-yl)-1H-1,2,3-triazole-4-carboxamide, pharmaceutical compositions, methods of use and methods of making thereof.

公开(公告)号：US20230147490A1

公开(公告)日：2023-05-11

申请号：US17871157

申请日：2022-07-22

Applicant: BIOGEN MA INC.

Inventor： Brian T. HOPKINS ,  Bin MA ,  Robin PRINCE ,  Isaac MARX ,  Joseph P. LYSSIKATOS ,  Fengmei ZHENG ,  Matthew PETERSON ,  Daniel B. PATIENCE

IPC: C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  A61P43/00 ,  C07D405/14 ,  C07D471/04 ,  A61P1/16

CPC classification number: C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  A61P43/00 ,  C07D405/14 ,  C07D471/04 ,  A61P1/16 ,  C07B2200/13

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.