公开(公告)号：US20160250340A1

公开(公告)日：2016-09-01

申请号：US15131233

申请日：2016-04-18

Applicant: BIOGEN MA INC.

Inventor： Blake PEPINSKY ,  Laura RUNKEL ,  Margot BRICKELMAIER ,  Adrian WHITTY ,  Paula HOCHMAN

IPC: A61K47/48 ,  A61K38/21

CPC classification number: A61K47/60 ,  A61K38/215 ,  A61K47/59 ,  A61K47/61 ,  Y10S930/142

Abstract: An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.

Abstract translation: 包含与包含聚亚烷基二醇部分的聚合物偶联的干扰素β1a的干扰素β多肽，其中所述干扰素-β-1a和聚亚烷基二醇部分被排列成使得干扰素-β-1a相对于另一种治疗形式具有增强的活性 干扰素β（干扰素-β-1b），并且与非结合的干扰素-β-1a相比，其活性没有降低。 本发明的缀合物有用地用于治疗以及非治疗性，例如诊断性应用。