Process for the preparation of 3-acetamido-5-aminobenzoic acid
    4.
    发明授权
    Process for the preparation of 3-acetamido-5-aminobenzoic acid 失效
    3-乙酰氨基-5-氨基苯甲酸的制备方法

    公开(公告)号:US3907880A

    公开(公告)日:1975-09-23

    申请号:US34122473

    申请日:1973-03-14

    Applicant: BOFORS AB

    CPC classification number: C07C233/00

    Abstract: 3-ACETAMIDO-5-AMINOBENZOIC ACID IS A VALUABLE INTERMEDIATE FOR THE PREPARATION OF DRUGS ESPECIALLY FOR CERTAIN TYPES OF IODINE COMPOUNDS WHICH ARE USED AS X-ray contrast agents. According to the present invention it is prepared by acetylating of 3,5diaminobenzoic acid in an aqueous solution in the presence of a mineral acid. The 3-acetamido-5-aminobenzoic acid is then obtained in the form of its salt of the mineral acid from which salt the desired free acid may be recovered by adding a base. The free acid is obtained in high yields and of high purity.

    Abstract translation: 3-乙酰氨基-5-氨基苯甲酸是用于制备药物的有价值的中间体,特别适用于作为X射线造影剂使用的某些类型的碘化合物。 根据本发明,通过在无机酸存在下在水溶液中乙酰化3,5-二氨基苯甲酸来制备。 然后以其无机酸盐的形式获得3-乙酰氨基-5-氨基苯甲酸,通过加入碱可从其中回收所需的游离酸。 以高产率和高纯度获得游离酸。

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