公开(公告)号：US20240218022A1

公开(公告)日：2024-07-04

申请号：US18509844

申请日：2023-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： JENNIFER X. QIAO ,  YUNHUI ZHANG ,  KENNETH M. BOY ,  MICHAEL A. POSS

IPC: C07K7/64

CPC classification number: C07K7/64

Abstract: This invention relates to novel anti-VISTA macrocyclic peptides and their related analogs with appended pharmacokinetic-enhancing tails (PKEs) with general structure of formula (I), which can be used as VISTA inhibitors.

公开(公告)号：US20240199701A1

公开(公告)日：2024-06-20

申请号：US18551319

申请日：2022-03-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： JENNIFER X. QIAO ,  MICHAEL A. POSS ,  YUNHUI ZHANG ,  MARTIN PATRICK ALLEN

IPC: C07K7/54 ,  A61K38/00 ,  A61K47/54

CPC classification number: C07K7/54 ,  A61K47/542 ,  A61K47/548 ,  A61K38/00

Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.