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公开(公告)号：US12279944B2
公开(公告)日：2025-04-22
申请号：US17389040
申请日：2021-07-29
Applicant: BVW Holding AG
Inventor： Lukas Bluecher , Michael Milbocker
IPC: A61F2/92 , A61F2/00 , A61F2/02 , A61L27/34 , A61L27/50 , A61L27/56 , A61L31/10 , A61L31/14 , B29C33/38
Abstract: Bio-adhesive textured surfaces and methods of making the same are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, may be employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described herein are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel, or Cassie-Wenzel state evolves. Further methods of making molds to produce said devices are described herein.
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公开(公告)号：US11963684B2
公开(公告)日：2024-04-23
申请号：US16823009
申请日：2020-03-18
Applicant: BVW Holding AG
Inventor： Michael Milbocker , Lukas Bluecher
CPC classification number: A61B17/12009 , A61F13/00021 , A61L31/042 , A61L31/044 , A61B2017/12004 , A61L2300/418
Abstract: A microstructured hemostat comprising multiple layers of microstructure, each layer characterized by one or more length scales, is described. Microstructured hemostats of the present invention, can reduce the time for blood coagulation, control the morphology of the coagulation, and provide a novel diagnostic platform for evaluation of coagulation function from a morphological perspective.
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公开(公告)号：US11857700B2
公开(公告)日：2024-01-02
申请号：US17175244
申请日：2021-02-12
Applicant: BVW Holding AG
Inventor： Lukas Bluecher , Kenneth Kleinhenz , Michael Milbocker
IPC: A61L27/00 , A61L27/58 , A61L27/18 , A61L31/06 , A61L27/34 , A61L31/10 , A61L27/22 , A61L31/14 , A61L27/30 , A61L31/04
CPC classification number: A61L27/58 , A61L27/18 , A61L27/22 , A61L27/34 , A61L31/06 , A61L31/10 , A61L31/148 , A61L27/30 , A61L31/043 , A61L27/34 , C08L75/04 , A61L27/18 , C08L75/04 , A61L31/10 , C08L75/04 , A61L31/06 , C08L75/04
Abstract: Polymer devices are disclosed with microstructured surfaces that modify their absorption pathway. Polymers which generally degrade in water by fracturing into high surface energy fragments, are modified to degrade in vivo without the formation of sharp fragments. Devices are disclosed that possess improved handling characteristics and degrade in an aqueous environment in a uniform and continuous way that favors the formation of soluble monomers rather than solid particulate. Absorbable medical implants with the disclosed surface modifications are more biocompatible, with reduced foreign body response, and dissolution into metabolizable molecular species.
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公开(公告)号：US11613461B2
公开(公告)日：2023-03-28
申请号：US15285529
申请日：2016-10-05
Applicant: BVW Holding AG
Inventor： Michael Milbocker , Lukas Bluecher
Abstract: The present invention relates to textile articles and clothing such as outdoor garments, indoor garments, and commercial protective wear exposed to contact mixtures of water and oil, swimwear and winter wear exposed to mixtures of water and air. At least part of these textile articles possess a surface provided with at least one of 1) a high surface area, 2) hierarchical pattern, 3) contact angles such that hydrophilic portion of a contact mixture possesses a high contact angle and the hydrophobic portion of a contact mixture possesses a low contact angle, and 4) hysteresis angle greater than 5 degrees. Hydrophobic/Hydrophilic contact mixtures of the present invention can be surfaces where water and or ice are present in combination with oil and or air. The textile articles of the present invention resist slippage on surfaces possessing hydrophobic/hydrophilic contact mixtures.
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公开(公告)号：US11419711B2
公开(公告)日：2022-08-23
申请号：US17389046
申请日：2021-07-29
Applicant: BVW Holding AG
Inventor： Lukas Bluecher , Michael Milbocker
Abstract: Bio-adhesive textured surfaces are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, may be employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described herein are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel, or Cassie-Wenzel state evolves. Further methods of making molds to produce said devices are described herein.
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Patent Agency Ranking
公开(公告)号：US20220161301A1
公开(公告)日：2022-05-26
申请号：US17669091
申请日：2022-02-10
Applicant: BVW Holding AG
Inventor： Michael Milbocker , Lukas Bluecher
Abstract: Provided herein is a hierarchical superhydrophobic surface comprising an array of first geometrical features disposed on a substrate comprising a first material and a terminal level disposed on the second features, wherein the terminal level comprises a second material, the second material being different from the first material. The second material has a hydrophilicity different from the hydrophilicity of at least one of 1) the hydrophilicity of the second material and 2) hydrophilicity induced by the hierarchical structure. The present disclosure further includes methods of preparing hierarchical superhydrophobic surfaces and medical devices comprising the hierarchical superhydrophobic surfaces.
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公开(公告)号：US11298440B2
公开(公告)日：2022-04-12
申请号：US17236738
申请日：2021-04-21
Applicant: BVW Holding AG
Inventor： Lukas Bluecher , Michael Milbocker
Abstract: The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.
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公开(公告)号：US20210353400A1
公开(公告)日：2021-11-18
申请号：US17389040
申请日：2021-07-29
Applicant: BVW Holding AG
Inventor： Lukas Bluecher , Michael Milbocker
Abstract: Bio-adhesive textured surfaces and methods of making the same are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, may be employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described herein are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel, or Cassie-Wenzel state evolves. Further methods of making molds to produce said devices are described herein.
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公开(公告)号：US20210290820A1
公开(公告)日：2021-09-23
申请号：US17236738
申请日：2021-04-21
Applicant: BVW Holding AG
Inventor： Lukas Bluecher , Michael Milbocker
Abstract: The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.
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公开(公告)号：US20210290241A1
公开(公告)日：2021-09-23
申请号：US16823009
申请日：2020-03-18
Applicant: BVW Holding AG
Inventor： Michael Milbocker , Lukas Bluecher
Abstract: A microstructured hemostat comprising multiple layers of microstructure, each layer characterized by one or more length scales, is described. Microstructured hemostats of the present invention, can reduce the time for blood coagulation, control the morphology of the coagulation, and provide a novel diagnostic platform for evaluation of coagulation function from a morphological perspective.
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