公开(公告)号：US20230287421A1

公开(公告)日：2023-09-14

申请号：US18090884

申请日：2022-12-29

Applicant: Bar-Ilan University

Inventor： Jean-Paul LELLOUCHE ,  Shulamit MICHAELI ,  Limor Liron ISRAEL ,  Emmanuel LELLOUCHE ,  Yekaterina KAPILOV-BUCHMAN

IPC: C12N15/113 ,  A61K9/51 ,  A61K33/26 ,  B82Y5/00 ,  B01J13/02 ,  C12N15/11 ,  C01G49/06 ,  A61K47/69 ,  A61K47/52 ,  A61K47/59 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K9/5115 ,  A61K33/26 ,  B82Y5/00 ,  B01J13/02 ,  C12N15/111 ,  C01G49/06 ,  A61K47/6923 ,  A61K47/6929 ,  A61K47/52 ,  A61K47/59 ,  A61K31/7088 ,  C12N2310/14 ,  C12N2320/32 ,  B82Y30/00

Abstract: A nanoparticle, which has a metal oxide core and a cerium shell is provided. The weight ratio of the cerium within the shell to the metal oxide in the core is at least 1%. Additionally a method for delivering a ligand into a cell with the nanoparticle is provided. Processes for making the nanoparticle which include: sonicating an aqueous composition containing Ceric Ammonium Nitrate and a prefabricated nano particle suspension; and (b) adding a polycationic polymer to the mixture (for NP surface functionalization), are also described.

公开(公告)号：US20230001364A1

公开(公告)日：2023-01-05

申请号：US17777447

申请日：2020-11-26

Applicant: BAR-ILAN UNIVERSITY

Inventor： Jean-Paul LELLOUCHE ,  Daniel ITSHAK ,  Yifat HAREL ,  Limor Liron ISRAEL ,  Esthy LEVY-EITAN

IPC: B01F31/80 ,  C01B32/28

Abstract: A disaggregation method for NDs (nanodiamonds) comprising: sonicating NDs dispersed in water; and sedimenting non-disaggregated NDs by centrifugation. Optionally, the method includes sonicating the disaggregated NDs with CAN [(NH4)2Ce(NO3)6] to produce CAN modified NDs and washing to remove excess CAN. Populations of disaggregated NDs are also disclosed. In some embodiments the populations are provided as an aqueous suspension.