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    Stent crack reduction
    1.
    发明申请
    Stent crack reduction 审中-公开
    支架裂缝减少

    公开(公告)号：US20080033523A1

    公开(公告)日：2008-02-07

    申请号：US11824155

    申请日：2007-06-29

    Applicant: David Gale ,  Daniel Castro ,  Bin Huang

    Inventor： David Gale ,  Daniel Castro ,  Bin Huang

    IPC: A61F2/84 ,  A61F2/82

    CPC classification number: A61F2/958 ,  A61B18/24 ,  A61F2250/0001

    Abstract: A medical device such as a stent with a catheter, delivery balloon and an infrared energy source is disclosed. The infrared energy source heats the delivery balloon, and/or the stent to a temperature above body temperature, thereby increasing the flexibility of the stent such that formation of cracks in the stent upon its expansion is reduced or eliminated. Either the delivery balloon, and/or the stent may include an infrared energy absorbing material.

    Abstract translation: 公开了一种医疗装置，例如具有导管，输送球囊和红外能量源的支架。 红外能量源将输送气球和/或支架加热到体温以上，从而增加支架的柔韧性，从而降低或消除支架在其膨胀时形成裂缝。 输送球囊和/或支架可以包括红外能量吸收材料。

    Method of fabricating an implantable medical device with biaxially oriented polymers
    3.
    发明申请
    Method of fabricating an implantable medical device with biaxially oriented polymers 审中-公开
    用双轴取向聚合物制造可植入医疗器械的方法

    公开(公告)号：US20060020330A1

    公开(公告)日：2006-01-26

    申请号：US10899948

    申请日：2004-07-26

    Applicant: Bin Huang ,  Stephen Schaible ,  Richard Kaufman ,  Jim Kennedy ,  David Gale ,  Suresh Amin ,  John Guardiano

    Inventor： Bin Huang ,  Stephen Schaible ,  Richard Kaufman ,  Jim Kennedy ,  David Gale ,  Suresh Amin ,  John Guardiano

    IPC: A61F2/06

    CPC classification number: A61F2/82 ,  A61F2/91 ,  A61F2002/825 ,  A61L31/148 ,  B23K2103/42 ,  B23K2103/50 ,  B29C48/0018 ,  B29C48/09 ,  B29C48/30 ,  B29C48/33 ,  B29C49/786 ,  B29L2031/7534

    Abstract: Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Some embodiments may include inducing molecular orientation by expansion of a molten annular polymer film. Other embodiments may include inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer. In certain embodiments, circumferential orientation may be induced by expansion of a polymer tube. Further embodiments may include manufacturing an implantable medical device from a biaxially oriented planar polymer film.

    Abstract translation: 本文描述了用于制造可植入医疗装置（例如支架）的方法和系统，其具有期望的机械性质（例如改善的周向强度和刚度）的管。 可以通过在用于制造可植入医疗装置的材料中诱导分子取向来获得改善的周向强度和刚性。 一些实施方案可以包括通过膨胀熔融的环状聚合物膜诱导分子取向。 其它实施方案可以包括通过诱导熔融聚合物中的圆周流动来诱导圆周分子取向 在某些实施方案中，可以通过聚合物管的膨胀来引起圆周取向。 另外的实施例可以包括从双轴取向的平面聚合物膜制造可植入医疗装置。

    Drug delivery after biodegradation of the stent scaffolding
    6.
    发明申请
    Drug delivery after biodegradation of the stent scaffolding 有权
    支架支架生物降解后的药物输送

    公开(公告)号：US20080051880A1

    公开(公告)日：2008-02-28

    申请号：US11823703

    申请日：2007-06-27

    Applicant: David Gale ,  Bin Huang

    Inventor： David Gale ,  Bin Huang

    IPC: A61F2/82

    CPC classification number: A61L31/14 ,  A61F2/82 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/604

    Abstract: Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.

    Abstract translation: 公开了一种支架，其包括生物可吸收聚合物支架; 以及在所述脚手架的至少一部分中的多个仓库，其中所述多个仓库包含生物可吸收材料，其中所述脚手架的所有或基本上全部所述生物可吸收聚合物的降解速度比全部或基本上 所有生物可吸收材料的仓库。

    Method of fabricating an implantable medical device to reduce chance of late inflammatory response
    10.
    发明申请
    Method of fabricating an implantable medical device to reduce chance of late inflammatory response 有权
    制造可植入医疗器械以减少炎症反应迟发的方法

    公开(公告)号：US20070253999A1

    公开(公告)日：2007-11-01

    申请号：US11444596

    申请日：2006-05-31

    Applicant: Bin Huang ,  David Gale

    Inventor： Bin Huang ,  David Gale

    IPC: A61F2/06

    CPC classification number: A61L31/06 ,  A61F2/915 ,  A61L31/148 ,  B23K26/402 ,  B23K2103/42 ,  B23K2103/50 ,  B29B13/02 ,  B29C71/0063 ,  B29L2031/7532 ,  C08L67/04

    Abstract: The invention provides a method for fabricating an implantable medical device to increase biocompatibility of the device, the method comprising: heat setting a polymer construct, wherein the polymer construct is at a temperature range of from about Tg to about 0.6(Tm−Tg)+Tg such that the set polymer construct comprises a crystalline structure having crystals at a size less than about 2 microns; and fabricating an implantable medical device from the heat set polymer construct.

    Abstract translation: 本发明提供一种用于制造可植入医疗装置以提高装置的生物相容性的方法，所述方法包括：热定形聚合物构造物，其中所述聚合物构造物的温度范围为约Tg至约0.6（Tm-Tg）+ Tg使得所述聚合物构件包含具有小于约2微米尺寸的晶体的晶体结构; 以及从所述热固性聚合物构造物制造可植入医疗装置。

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