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公开(公告)号：US09877728B2
公开(公告)日：2018-01-30
申请号：US15447712
申请日：2017-03-02
Applicant: Biolife, L.L.C.
Inventor： John Hen , Talmadge Kelly Keene , Mark Travi
CPC classification number: A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.
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公开(公告)号：US08961479B2
公开(公告)日：2015-02-24
申请号：US13847057
申请日：2013-03-19
Applicant: Biolife, L.L.C.
Inventor： John Hen , Talmadge Kelly Keene , Mark Travi
CPC classification number: A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.
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公开(公告)号：US09757412B2
公开(公告)日：2017-09-12
申请号：US14446682
申请日：2014-07-30
Applicant: Biolife, L.L.C.
Inventor： Talmadge Kelley Keene , John Hen
Abstract: A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.
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公开(公告)号：US20140341837A1
公开(公告)日：2014-11-20
申请号：US14446682
申请日：2014-07-30
Applicant: Biolife, L.L.C.
Inventor： Talmadge Kelley Keene , John Hen
IPC: A61K31/79
Abstract: A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.
Abstract translation: 用于促进止血，吸收渗透和对开放伤口进行抗菌的组合物和方法。 组合物广泛地包括抗微生物剂，优选聚维酮碘，优选高铁酸盐化合物和阳离子交换树脂。 该组合物将破坏在开放伤口上形成的生物膜，以提供可溶性铁化合物，阳离子螯合化合物和对浮游微生物和生物膜有效的活性抗微生物化合物。 将抗微生物剂锁定或密封在伤口上形成的痂内，以保持抗菌剂在伤口上的长期定位和抗稀释。
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公开(公告)号：US20170172582A1
公开(公告)日：2017-06-22
申请号：US15447712
申请日：2017-03-02
Applicant: Biolife, L.L.C.
Inventor： John Hen , Talmadge Kelly Keene , Mark Travi
CPC classification number: A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.
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Patent Agency Ranking
公开(公告)号：US20150257766A1
公开(公告)日：2015-09-17
申请号：US14545560
申请日：2015-05-21
Applicant: Biolife, L.L.C.
Inventor： John Hen , Talmadge Kelly Keene , Mark Travi
IPC: A61B17/12
CPC classification number: A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.
Abstract translation: 止血片优选包括高铁酸钾和形成片剂的阳离子离子交换树脂压力，用于输送到出血伤口。 与片状的止血粉末的薄层相比，该片剂改善了与出血的伤口表面的粘附速度，并且通过手动压片片剂可以显着地提高和更均匀的压力。 在由血液或渗出物与片剂的直接接触表面的相互作用形成密封之后，大部分未使用的片剂容易从密封层剥离，从而使清洁容易。 如果片剂的未使用部分没有从伤口部位移除，则止血敷料的储存器停止进一步渗血并提供抗微生物保护和愈合。 片剂可以应用于任何表面取向并且可以具有任何形状和厚度。
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公开(公告)号：US09039667B1
公开(公告)日：2015-05-26
申请号：US14606324
申请日：2015-01-27
Applicant: Biolife, L.L.C.
Inventor： John Hen , Talmadge Kelly Keene , Mark Travi
CPC classification number: A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
Abstract: A method of arresting blood flow from a bleeding wound including the steps of (1) providing a solid hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery onto a bleeding wound, the tablet defining a proximal portion and a distal portion, (2) applying the proximal portion against the bleeding wound to improve the rate of adhesion to a bleeding wound surface, and then (3) applying pressure against the tablet over the wound site. After the seal is formed from the interaction of blood or exudates with the proximal portion of the tablet, the distal portion of the tablet delaminates from the proximal portion to form a reservoir to stop further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.
Abstract translation: 一种阻止来自出血伤口的血液流动的方法，包括以下步骤：（1）提供固体止血片，其优选包括高铁酸钾和阳离子交换树脂压力形成片剂以输送到出血的伤口上，所述片剂限定近端部分 和远端部分，（2）将近端部分施加到出血的伤口上，以提高与出血的伤口表面的粘附速率，然后（3）在伤口部位上对片剂施加压力。 在由血液或渗出物与片剂的近端部分的相互作用形成密封件之后，片剂的远端部分从近端部分分层形成储存器以停止进一步的渗血并提供抗微生物保护和愈合。 片剂可以应用于任何表面取向并且可以具有任何形状和厚度。
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公开(公告)号：US08979726B2
公开(公告)日：2015-03-17
申请号：US13760319
申请日：2013-02-06
Applicant: Biolife, L.L.C.
Inventor： John Hen , Talmadge Kelly Keene , Mark Travi
CPC classification number: A61K33/26 , A61K9/0009 , A61K9/0014 , A61K31/74 , A61L15/42 , A61L2400/04 , A61N2/002 , A61K2300/00
Abstract: A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound.
Abstract translation: 一种阻止血液从出血伤口流出的组合物和方法。 该组合物优选包括与有效量的不溶性阳离子交换材料和有效量的无机混合的无水高铁酸盐化合物。 可以加入聚维酮碘以提高抗菌性能。 在该方法中，将一定量的组合物磁性地附着在磁体的表面上，然后通过将粉末状化合物覆盖的表面压在伤口上足以使血液凝结的时间将粉末混合物施加到伤口上 阻止伤口进一步的血液流动。
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公开(公告)号：US09585671B2
公开(公告)日：2017-03-07
申请号：US14545560
申请日：2015-05-21
Applicant: Biolife, L.L.C.
Inventor： John Hen , Talmadge Kelly Keene , Mark Travi
IPC: A61M35/00 , A61B17/12 , A61L15/18 , A61L24/00 , A61L24/06 , A61M5/178 , A61F13/36 , A61F13/00 , A61B17/00 , A61L15/60 , A61M25/02
CPC classification number: A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
Abstract: A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.
Abstract translation: 止血片优选包括高铁酸钾和形成片剂的阳离子离子交换树脂压力，用于输送到出血伤口。 与片状的止血粉末的薄层相比，该片剂改善了与出血的伤口表面的粘附速度，并且通过手动压片片剂可以显着地提高和更均匀的压力。 在由血液或渗出物与片剂的直接接触表面的相互作用形成密封之后，大部分未使用的片剂容易从密封层剥离，从而使清洁容易。 如果片剂的未使用部分没有从伤口部位移除，则止血敷料的储存器停止进一步渗血并提供抗微生物保护和愈合。 片剂可以应用于任何表面取向并且可以具有任何形状和厚度。
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公开(公告)号：US20150147392A1
公开(公告)日：2015-05-28
申请号：US14606324
申请日：2015-01-27
Applicant: Biolife, L.L.C.
Inventor： John Hen , Talmadge Kelly Keene , Mark Travi
IPC: A61L15/18
CPC classification number: A61B17/12159 , A61B17/0057 , A61B17/12163 , A61B2017/00004 , A61B2017/12004 , A61B2017/12054 , A61F13/00 , A61F13/36 , A61F2013/00412 , A61F2013/00472 , A61L15/18 , A61L15/60 , A61L24/0015 , A61L24/02 , A61L24/06 , A61L2300/102 , A61L2300/418 , A61L2400/04 , A61M25/02 , A61M35/00 , A61M35/003 , A61M35/006 , C08L25/18
Abstract: A method of arresting blood flow from a bleeding wound including the steps of (1) providing a solid hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery onto a bleeding wound, the tablet defining a proximal portion and a distal portion, (2) applying the proximal portion against the bleeding wound to improve the rate of adhesion to a bleeding wound surface, and then (3) applying pressure against the tablet over the wound site. After the seal is formed from the interaction of blood or exudates with the proximal portion of the tablet, the distal portion of the tablet delaminates from the proximal portion to form a reservoir to stop further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.
Abstract translation: 一种阻止来自出血伤口的血液流动的方法，包括以下步骤：（1）提供固体止血片，其优选包括高铁酸钾和阳离子交换树脂压力形成片剂以输送到出血的伤口上，所述片剂限定近端部分 和远端部分，（2）将近端部分施加到出血的伤口上，以提高与出血的伤口表面的粘附速率，然后（3）在伤口部位上对片剂施加压力。 在由血液或渗出物与片剂的近端部分的相互作用形成密封件之后，片剂的远端部分从近端部分分层形成储存器以停止进一步的渗血并提供抗微生物保护和愈合。 片剂可以应用于任何表面取向并且可以具有任何形状和厚度。
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