公开(公告)号：US20240085286A1

公开(公告)日：2024-03-14

申请号：US18514320

申请日：2023-11-20

Applicant: BrightSpec, Inc.

Inventor： Voislav Blagojevic ,  Chris Thompson ,  Justin L. Neill

IPC: G01N1/40 ,  G01N1/02 ,  G01N30/72 ,  G01N30/86

CPC classification number: G01N1/4022 ,  G01N1/02 ,  G01N30/7246 ,  G01N30/7253 ,  G01N30/86 ,  G01N2001/028 ,  H01J49/165

Abstract: Molecular rotational resonance (MRR) spectroscopy can be used to characterize neutral, gas-phase molecules with very fine spectral resolution. Typically, the analyte molecules are placed in solution, which is heated initially to evaporate the solvent, then heated more to volatilize the analyte. Unfortunately, this approach does not always work well for analytes with low volatilities or susceptibility to thermal degradation. These analytes can be volatilized instead using laser-induced acoustic desorption (LIAD), flash vaporization, or nebulization. In LIAD, the analyte is dried onto a metal foil, which is illuminated by a laser. The laser beam generates an acoustic wave in the metal foil that shakes off the analyte. In flash vaporization, a small amount of liquid analyte drips onto a very hot surface, where it vaporizes too quickly to degrade. And in nebulization, a nebulizer pumps a fine spray of analyte into a heated transfer tube, where the solvent evaporates.