公开(公告)号：US3778476A

公开(公告)日：1973-12-11

申请号：US3778476D

申请日：1970-05-11

Applicant: CALIFORNIA INST OF TECHN

Inventor： KEYZER H ,  REMBAUM A ,  LANDEL R

IPC: C08G18/08 ,  C08G73/02 ,  D06M16/00 ,  C07C87/30 ,  C08G33/02 ,  C08G33/06

CPC classification number: C08G73/0226 ,  C08G18/0814 ,  C08G73/02 ,  D06M16/00

Abstract: HALOGEN CONTAINING POLYMER SALTS FORMED FRO THE REACTION OF LINEAR POLYMERS CONTAINING QUATERNIZABLE NITROGENTS DISSOLVED IN A SUITABLE SOLVENT, WITH A HALOGEN SOURCE UNDER CONDITIONS SUFFICIENT TO PRECIPITATE THE HALOGEN CONTAINING POLYMER SALTS FROM THE SOLUTION.

公开(公告)号：US3755218A

公开(公告)日：1973-08-28

申请号：US3755218D

申请日：1970-08-14

Applicant: CALIFORNIA INST OF TECHN

Inventor： SIAO YEN S ,  REMBAUM A

IPC: A61L33/00 ,  A61M25/16 ,  C08G18/08 ,  C08G18/10 ,  C08G18/32 ,  C08L75/04 ,  A61K17/18 ,  C08B25/00

CPC classification number: C08G18/329 ,  A61L33/0023 ,  C08G18/0814 ,  C08G18/10 ,  C08G18/3275 ,  C08L75/04 ,  Y10S128/22 ,  Y10T428/1345 ,  Y10T428/31554 ,  Y10T428/31565 ,  Y10T428/31587 ,  Y10T428/31598 ,  Y10T428/31601 ,  C08L75/00 ,  C08L2666/26

Abstract: A neutral elastomer is prepared by the urethane linking reaction of diisocyanates with tertiary amino diols. The neutral elastomer is quaternized and is then reacted with an anionic polymer such as heparin to form ionically bonded block elastomeric copolymers. The heparin copolymer has non-thrombogenic characteristics. It can be dissolved in solvents and utilized to form a non-clotting coat on the blood lines in kidney machines.

Abstract translation: 通过二异氰酸酯与叔氨基二醇的氨基甲酸酯连接反应制备中性弹性体。 中性弹性体被季铵化，然后与阴离子聚合物例如肝素反应以形成离子键结合的弹性体共聚物。 肝素共聚物具有非血栓形成特征。 它可以溶解在溶剂中，用于在肾脏机器的血液线上形成非凝血层。

公开(公告)号：US3853804A

公开(公告)日：1974-12-10

申请号：US36847573

申请日：1973-07-16

Applicant: CALIFORNIA INST OF TECHN

Inventor： YEN S ,  REMBAUM A

IPC: A61L33/00 ,  C08G18/08 ,  C08G18/10 ,  C08G18/32 ,  C08L75/04 ,  B44D1/09 ,  C08G51/44 ,  C08K1/40

CPC classification number: C08G18/329 ,  A61L33/0023 ,  C08G18/0814 ,  C08G18/10 ,  C08G18/3275 ,  C08L75/04 ,  C08L75/00 ,  C08L2666/26

Abstract: A neutral elastomer is prepared by the urethane linking reaction of diisocyanates with tertiary amino diols. The neutral elastomer is quaternized and is then reacted with an anionic polymer such as heparin to form ionically bonded block elastomeric copolymers. The heparin copolymer has non-thrombogenic characteristics. It can be dissolved in solvents and ultized to form a non-clotting coat on the blood lines in kidney machines.

Abstract translation: 通过二异氰酸酯与叔氨基二醇的氨基甲酸酯连接反应制备中性弹性体。 中性弹性体被季铵化，然后与阴离子聚合物例如肝素反应以形成离子键结合的弹性体共聚物。 肝素共聚物具有非血栓形成特征。 它可以溶解在溶剂中，最终在肾脏机器的血液线上形成非凝固的涂层。

公开(公告)号：US3754055A

公开(公告)日：1973-08-21

申请号：US3754055D

申请日：1970-12-28

Applicant: CALIFORNIA INST OF TECHN

Inventor： REMBAUM A

IPC: B01J41/14 ,  C08F20/08 ,  C08J5/22 ,  C08F1/16 ,  C08F7/12

CPC classification number: C08J5/2231 ,  B01J41/14 ,  C08F20/08 ,  C08J2339/08 ,  Y10T428/249954 ,  Y10T428/2933 ,  Y10T428/2993 ,  Y10T428/31855 ,  Y10T428/31993 ,  Y10T436/25375

Abstract: QUATERNIZED, COSS-LINKAGE, INSOLUBLE COPOLYMERS OF UNSUBSUBSTITUTED AND SBSTITUTED VINYL PYRIDINES AND A DIHALO ORGAINC COMPOUNDS ARE SPONTANEOUSLY FORMED AT AMBIENT TEMPERATURE ON MIXING THE TWO MONOMERS IN BULK, IN SOLUTION OR IN SUSPENSION. THE AMOUNT OF CROSS-LINKING MAY BE VARIED ACCORDING TO THE COMPOSITION AND REACTION CNDITIONS. THE POLYMER PRODUCT EXHIBITS ION EXCHAGE CAPACITY AND UNDERGOES A REVERSIBLE COLOR CHANGE FROM BLACK AT A PH ABOVE 7 TO YELLOW AT A PH BELOW 7. THE POLYMER MAY BE FORMED IN THE PRESENCE OF PERFORMED POLYMERS, SUBSTRATES SUCH AS POROUS OR IMPERIOUS PARTICLES OR FILMS TO DEPOSIT AN ION EXCHANGE FILM IN SITU OR ON THE SURFACE OF THESUBSTRATE. THE COATED OR RESIN IMPREGNATED SUBSTRATE MAY BE UTILIZED FOR SEPARATION OF ANIONIC SPECIES FROM AQUEOUS SOLUTION.