-
公开(公告)号：US20220308048A1
公开(公告)日：2022-09-29
申请号：US17839831
申请日：2022-06-14
Applicant: Case Western Reserve University
Inventor： Susann Brady-Kalnay , Robert Deissler , Robert Brown
IPC: G01N33/543 , G01N33/58 , G01N33/569 , G01N21/64 , G01N21/11
Abstract: Early stage, rapid, low-cost detection of disease components in a biological sample is critically important. A point of care device can include a collection region and can be used to hold a sample that is combined with a fluorescent dye and a plurality of magnetic particles such that disease components in the sample are tagged with the fluorescent dye and the plurality of magnetic particles. At least one magnet can be located next to the collection region to establish a magnetic field gradient to draw the tagged disease components into the collection region from the device. A fluorescence microscope can image the small collection region based on the fluorescent dye to detect the disease components. The fluorescence microscope uses light to excite the fluorescent dye and a filter to transmit light emitted by the fluorescent dye to the fluorescence microscope, while restricting light used to excite the fluorescent dye.
-
公开(公告)号：US20150377857A1
公开(公告)日：2015-12-31
申请号：US14766523
申请日：2014-02-10
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Brian T. Grimberg , Robert Deissler , William Condit , Robert Brown , Jason Jones , Richard Bihary
CPC classification number: G01N33/48 , G01N1/28 , G01N21/21 , G01N21/59 , G01N33/49 , G01N2201/06113 , G01N2201/0683
Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.
Abstract translation: 提供一种诊断装置，其包括用于将光束通过血液样本传输到光检测器的光源和永磁体，其中永磁体和血液样本中的一个可自动地相对于另一个在“HIGH” 磁状态位置和“低”磁状态位置，使得基本上高的磁场被施加到血液样本，导致血样中的任何血红素趋向于垂直取向于大体上的磁场，并抑制或增强光 基于其极化，并且将零到接近零的磁场施加到血液样品，导致血液样品中任何血红素的随机化，并且基线量的光通过血液样本在“低”磁性 状态。
-
公开(公告)号：US20210389315A1
公开(公告)日：2021-12-16
申请号：US17347892
申请日：2021-06-15
Applicant: Case Western Reserve University
Inventor： Susann Brady-Kalnay , Robert Deissler , Robert Brown
IPC: G01N33/543 , G01N33/569
Abstract: Early stage, rapid, low-cost, and accurate detection of disease components in a biological fluid is critically important. A point of care device can use functionalized magnetic beads to facilitate this detection. The device can include a sample holder with a collection region. A magnet can be used to draw the functionalized nanoparticles bound to the disease component into the collection region, where the disease component is captured. A light source can shine a light beam through the collection region; and a detector can detect the light beam after traversing the collection region to determine whether the disease component is present in the sample.
-
Patent Agency Ranking
公开(公告)号：US20200085340A1
公开(公告)日：2020-03-19
申请号：US16134338
申请日：2018-09-18
Applicant: Case Western Reserve University
Inventor： Tanvir Baig , Robert Deissler , Brian Grimberg , Robert Brown , Michael Martens
IPC: A61B5/05 , A61B5/00 , G01N33/543 , G01N33/569
Abstract: A system is described herein that can be used to perform magneto-optical detection of a disease component in a test sample using magnetic nanoparticles. A concentration of magnetic nanoparticles and a concentration of bindable agents can be administered to the test sample. The magnetic nanoparticles can be configured to attach to the bindable agents. A light beam can be transmitted through the test sample to a light detector. A magnetic field gradient can be established through the test sample. If the transmitted light beam under the magnetic field gradient exhibits a variable intensity change during a time period, the disease component can be determined to exist in the test sample.
-
公开(公告)号：US09778245B2
公开(公告)日：2017-10-03
申请号：US15425729
申请日：2017-02-06
Applicant: Case Western Reserve University
Inventor： Brian T. Grimberg , Robert Deissler , William Condit , Robert Brown , Jason Jones , Richard Bihary
CPC classification number: G01N33/48 , G01N1/28 , G01N21/21 , G01N21/59 , G01N33/49 , G01N2201/06113 , G01N2201/0683
Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.
-
公开(公告)号：US20170146513A1
公开(公告)日：2017-05-25
申请号：US15425729
申请日：2017-02-06
Applicant: Case Western Reserve University
Inventor： Brian T. Grimberg , Robert Deissler , William Condit , Robert Brown , Jason Jones , Richard Bihary
CPC classification number: G01N33/48 , G01N1/28 , G01N21/21 , G01N21/59 , G01N33/49 , G01N2201/06113 , G01N2201/0683
Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.
-
公开(公告)号：US09575052B2
公开(公告)日：2017-02-21
申请号：US14766523
申请日：2014-02-10
Applicant: Case Western Reserve University
Inventor： Brian T. Grimberg , Robert Deissler , William Condit , Robert Brown , Jason Jones , Richard Bihary
CPC classification number: G01N33/48 , G01N1/28 , G01N21/21 , G01N21/59 , G01N33/49 , G01N2201/06113 , G01N2201/0683
Abstract: A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “HIGH” magnetic state position and a “LOW” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “LOW” magnetic state position.
Abstract translation: 提供一种诊断装置，其包括用于将光束通过血液样本传输到光检测器的光源和永磁体，其中永磁体和血液样本中的一个可自动地相对于另一个在“HIGH” 磁状态位置和“低”磁状态位置，使得基本上高的磁场被施加到血液样本，导致血样中的任何血红素趋向于垂直取向于大体上的磁场，并抑制或增强光 基于其极化，并且将零到接近零的磁场施加到血液样品，导致血液样品中任何血红素的随机化，并且基线量的光通过血液样本在“低”磁性 状态。
-
公开(公告)号：US20210109094A1
公开(公告)日：2021-04-15
申请号：US17068152
申请日：2020-10-12
Applicant: Case Western Reserve University
Inventor： Robert Deissler , Brian Grimberg , Umut Gurkan , Susann Brady-Kalnay , Robert Brown , Yuncheng Man , Ran An
IPC: G01N33/543 , B01L3/00 , G01N21/64
Abstract: Disease components can be detected in a fluid using magnetic particles and microfluidics. Magnetic particles are combined with a sample in a fluid. The sample may include disease components. The magnetic particles can be configured to tag any disease components within the sample. The fluid can be forced into a microchamber with two microcompartments. In the first microcompartment, the fluid can be exposed to a magnetic field and/or magnetic field gradient. The tagged disease component can be trapped by the magnetic field and/or magnetic field gradient due to the magnetic particles, allowing nonmagnetic components of the fluid to be washed away while the tagged disease components remain trapped by the magnetic field and/or magnetic field gradient. Then, the disease components can be forced into a more narrow second microcompartment and detected using optical instruments.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.024 seconds)
