公开(公告)号：US20150368181A1

公开(公告)日：2015-12-24

申请号：US14764833

申请日：2013-10-31

Applicant: COUNCIL OF SCIENTIFIC 7 INDUSTRIAL RESEARCH

Inventor： Rukhsana Ilyas KURESHY ,  Noor-Ul-Hasan KHAN ,  Sayed Hasan Razi ABDI ,  Hari Chand BAJAJ ,  Tamal ROY ,  Anjan DAS

IPC: C07C201/12 ,  C07F1/08 ,  C07F15/02 ,  C07F15/06 ,  C07F11/00 ,  B01J31/18 ,  C07F3/06

CPC classification number: C07C201/12 ,  B01J31/1805 ,  B01J31/2217 ,  B01J2231/342 ,  B01J2531/0252 ,  B01J2531/16 ,  B01J2531/26 ,  B01J2531/62 ,  B01J2531/842 ,  B01J2531/845 ,  C07F1/08 ,  C07F3/06 ,  C07F11/00 ,  C07F15/02 ,  C07F15/06

Abstract: The present invention relates to preparation of highly efficient chiral recyclable homogeneous catalysts generated in situ by the reaction of chiral oligomeric [H4] ligands and a metal salt taken in 1:1 molar ratio for asymmetric nitroaldol reaction, wherein nitroaldol reactions of various aldehydes such as aromatic, aliphatic α,β-unsaturated aldehydes, alicyclic aldehydes and nitroalkenes were carried out to produce optically active β-nitroalcohols in high yield and with moderate to excellent enantioselectivity (ee up to >95%) in presence of a base and an optically active chiral recyclable homogeneous catalyst represented by the following formula (I).

Abstract translation: 本发明涉及通过手性低聚[H 4]配体与1：1摩尔比的金属盐反应而产生的高效手性可回收的均相催化剂的制备，其中不对称的硝基醛醇反应，其中各种醛类的硝基醛醇反应如 芳香族，脂肪族α，β-不饱和醛，脂环族醛和硝基烯烃，以高产率和中等至优异的对映选择性（ee至95％以上）在碱存在下制备光学活性的α-硝基醇 由下式（I）表示的光学活性手性可回收均相催化剂。