公开(公告)号：US20130296833A1

公开(公告)日：2013-11-07

申请号：US13939720

申请日：2013-07-11

Applicant: Covidien LP

Inventor： PHILLIP D. BLASKOVICH ,  RACHIT OHRI ,  STEVEN L. BENNETT

IPC: A61K9/00

CPC classification number: A61K9/0004 ,  A61K9/0024

Abstract: The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.

Abstract translation: 本公开涉及一种药物递送装置，其包括可生物降解的壳体内的可生物降解的壳体和水凝胶。 壳体，水凝胶或两者可以包括生物活性剂。 还公开了药物递送的方法，包括形成可生物降解的壳体的步骤，在实施方案中为水凝胶，将生物活性剂悬浮在水凝胶中，以及将第二水凝胶和/或第二水凝胶的前体引入可生物降解的壳体中。

公开(公告)号：US20150065964A1

公开(公告)日：2015-03-05

申请号：US14011414

申请日：2013-08-27

Applicant: COVIDIEN LP

Inventor： RACHIT OHRI ,  LAN PHAM ,  PHILLIP D. BLASKOVICH ,  LES HULL ,  RUPAL AYER ,  STEPHEN H. WU ,  CLIFFORD J. HERMAN ,  WILLIAM H. NAU, JR. ,  FRANCESCA ROSSETTO ,  ALLISON WALLER ,  WENXING HUANG ,  PAUL DICARLO ,  MANTAO XU ,  XINGYAN LU ,  JIAGUI LI ,  QINLIN GU ,  HAROLD M. MARTINS

IPC: A61M5/32 ,  A61B18/14

CPC classification number: A61M5/329 ,  A61B17/3421 ,  A61B17/3478 ,  A61B18/1477 ,  A61B18/1487 ,  A61B2017/3447 ,  A61B2018/00577 ,  A61B2018/143 ,  A61B2218/002 ,  A61M25/00 ,  A61M25/0097 ,  A61M2025/0037 ,  A61M2202/0007

Abstract: A drug-delivery cannula assembly includes a cannula housing adapted for receiving at least one obturator shaft of an obturator assembly therethrough, one or more cannulae, and a supply line coupled to the cannula housing. The cannula housing is adapted for receiving one or more obturator shafts of an obturator assembly therethrough. The one or more cannulae define a longitudinal axis and a passageway aligned with the longitudinal axis. The one or more cannulae each include a proximal end coupled to the cannula housing. The cannula housing is configured to fluidly-couple the one or more cannulae to a source of a drug delivery supply for supplying drugs via the supply line to the one or more cannulae.

Abstract translation: 药物递送插管组件包括套管壳体，其适于容纳通过其中的闭孔器组件的至少一个闭塞轴，一个或多个套管以及耦合到插管壳体的供给管线。 插管壳体适于接收通过其中的闭孔器组件的一个或多个闭塞轴。 一个或多个套管限定纵向轴线和与纵向轴线对齐的通道。 一个或多个插管每个包括联接到插管壳体的近端。 套管壳体构造成将一个或多个套管流体耦合到药物递送供应源，用于通过供应管线向一个或多个套管提供药物。

公开(公告)号：US20150065944A1

公开(公告)日：2015-03-05

申请号：US14011438

申请日：2013-08-27

Applicant: COVIDIEN LP

Inventor： RACHIT OHRI ,  LAN PHAM ,  PHILLIP D. BLASKOVICH ,  LES HULL ,  RUPAL AYER ,  STEPHEN H. WU ,  CLIFFORD J. HERMAN ,  WILLIAM H. NAU, JR. ,  FRANCESCA ROSSETTO ,  ALLISON WALLER ,  WENXING HUANG ,  PAUL DICARLO

IPC: A61B18/14 ,  A61M37/00

CPC classification number: A61M37/00 ,  A61B10/0233 ,  A61B10/06 ,  A61B18/1477 ,  A61B18/18 ,  A61B18/1815 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00577 ,  A61B2018/00946 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2018/1869 ,  A61B2034/2065 ,  A61B2218/002 ,  A61M5/007 ,  A61M5/158 ,  A61M5/48 ,  A61M2037/0007 ,  A61M2205/0266 ,  A61M2205/055 ,  A61N1/0428 ,  A61N1/306 ,  A61N5/022 ,  A61N5/045

Abstract: A drug-delivery device includes a body configured for attachment to a handle of an ablation device, a shaft portion defining a passageway therein, and a delivery lumen to provide for drug delivery to tissue. The body includes a proximal portion, a distal portion, and a contoured portion disposed therebetween. The contoured portion is configured for engagement with a contoured portion of the handle of the ablation device. The shaft portion includes a proximal end and a distal end. The proximal end of the shaft engages with an opening defined in the distal end of the body. The passageway of the shaft portion is configured to receive the delivery lumen slideably moveably therein. The delivery lumen includes a proximal portion and a distal portion. The drug-delivery device also includes a knob member coupled to the proximal portion of the delivery lumen.

Abstract translation: 药物递送装置包括构造成附接到消融装置的手柄的主体，在其中限定通道的轴部分和用于向组织提供药物输送的输送腔。 主体包括近端部分，远侧部分和设置在其间的轮廓部分。 轮廓部分构造成与消融装置的手柄的轮廓部分接合。 轴部包括近端和远端。 轴的近端与限定在主体的远端中的开口接合。 轴部分的通道被构造成在其中可移动地容纳可滑动的输送腔。 输送腔包括近端部分和远端部分。 药物递送装置还包括联接到输送腔的近端部分的旋钮构件。

公开(公告)号：US20170087345A1

公开(公告)日：2017-03-30

申请号：US15379061

申请日：2016-12-14

Applicant: COVIDIEN LP

Inventor： RACHIT OHRI ,  LAN PHAM ,  PHILLIP D. BLASKOVICH ,  LES HULL ,  RUPAL AYER ,  STEPHEN H. WU ,  CLIFFORD J. HERMAN ,  WILLIAM H. NAU, JR. ,  FRANCESCA ROSSETTO ,  ALLISON WALLER ,  WENXING HUANG ,  PAUL DICARLO

IPC: A61M37/00 ,  A61M5/00 ,  A61N5/04 ,  A61N1/04 ,  A61N1/30 ,  A61N5/02 ,  A61B18/14 ,  A61M5/158

CPC classification number: A61M37/00 ,  A61B10/0233 ,  A61B10/06 ,  A61B18/1477 ,  A61B18/18 ,  A61B18/1815 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00577 ,  A61B2018/00946 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2018/1869 ,  A61B2034/2065 ,  A61B2218/002 ,  A61M5/007 ,  A61M5/158 ,  A61M5/48 ,  A61M2037/0007 ,  A61M2205/0266 ,  A61M2205/055 ,  A61N1/0428 ,  A61N1/306 ,  A61N5/022 ,  A61N5/045

Abstract: A drug-delivery device includes a body configured for attachment to a handle of an ablation device, a shaft portion defining a passageway therein, and a delivery lumen to provide for drug delivery to tissue. The body includes a proximal portion, a distal portion, and a contoured portion disposed therebetween. The contoured portion is configured for engagement with a contoured portion of the handle of the ablation device. The shaft portion includes a proximal end and a distal end. The proximal end of the shaft engages with an opening defined in the distal end of the body. The passageway of the shaft portion is configured to receive the delivery lumen slideably moveably therein. The delivery lumen includes a proximal portion and a distal portion. The drug-delivery device also includes a knob member coupled to the proximal portion of the delivery lumen.

公开(公告)号：US20130324911A1

公开(公告)日：2013-12-05

申请号：US13904478

申请日：2013-05-29

Applicant: COVIDIEN LP

Inventor： RACHIT OHRI ,  LAN PHAM ,  PHILLIP D. BLASKOVICH ,  LES HULL ,  RUPAL AYER ,  STEPHEN H. WU ,  CLIFFORD J. HERMAN ,  WILLIAM H. NAU, Jr. ,  FRANCESCA ROSSETTO ,  ALLISON WALLER ,  RICHARD HUANG ,  PAUL DICARLO

IPC: A61B18/14 ,  A61M5/158

CPC classification number: A61B18/1477 ,  A61B2018/00023 ,  A61B2018/00196 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00946 ,  A61B2018/143 ,  A61M5/158 ,  A61M25/0045 ,  A61M25/007 ,  A61M2025/0089 ,  A61M2025/0093

Abstract: An ablation system includes a source of electrosurgical energy, a source of coolant fluid, and an ablation electrode assembly operatively connected to the source of electrosurgical energy and fluidly-coupled to the source of coolant fluid. The ablation electrode assembly includes a hub defining a chamber therein and one or more electrically-conductive ablation needles extending from the hub. The ablation system also includes one or more delivery needles extending from the hub. The one or more delivery needles are selectively moveable from a first position, wherein the distal end of the delivery needle is disposed proximal to the distal end portion of the ablation needle, to at least a second position, wherein at least the distal end of the delivery needle is disposed distally beyond the distal end portion of the ablation needle.

Abstract translation: 消融系统包括电外科能量源，冷却剂流体源和可操作地连接到电外科能量源并且流体耦合到冷却剂流体源的消融电极组件。 消融电极组件包括在其中限定腔室的毂，以及从毂延伸的一个或多个导电消融针。 消融系统还包括从轮毂延伸的一个或多个输送针。 一个或多个输送针可以从第一位置选择性地移动，其中输送针的远端设置在消融针的远端部分附近，至少第二位置，其中至少第二位置的远端 输送针远离切除针的远端部分设置。

公开(公告)号：US20130324910A1

公开(公告)日：2013-12-05

申请号：US13871142

申请日：2013-04-26

Applicant: COVIDIEN LP

Inventor： RACHIT OHRI ,  STEPHEN H. WU ,  LES HULL, JR. ,  PHILLIP D. BLASKOVICH ,  LAN PHAM ,  WILLIAM H. NAU, JR. ,  FRANCESCA ROSSETTO ,  RUPAL AYER

IPC: A61B10/02 ,  A61M5/158 ,  A61B18/14

CPC classification number: A61M37/00 ,  A61B10/0233 ,  A61B10/06 ,  A61B18/1477 ,  A61B18/18 ,  A61B18/1815 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00577 ,  A61B2018/00946 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2018/1869 ,  A61B2034/2065 ,  A61B2218/002 ,  A61M5/007 ,  A61M5/158 ,  A61M5/48 ,  A61M2037/0007 ,  A61M2205/0266 ,  A61M2205/055 ,  A61N1/0428 ,  A61N1/306 ,  A61N5/022 ,  A61N5/045

Abstract: An ablation device includes a handle assembly, an ablation electrode extending from the handle assembly, and one or more delivery needles extending from the handle assembly. The ablation electrode includes an ablation needle. The ablation needle includes a distal end portion including a drug delivery port defined therethrough. The ablation device also includes and a biopsy tool extending from the handle assembly.

Abstract translation: 消融装置包括手柄组件，从手柄组件延伸的消融电极以及从手柄组件延伸的一个或多个输送针。 消融电极包括消融针。 消融针包括包括通过其限定的药物输送端口的远端部分。 消融装置还包括从手柄组件延伸的活检工具。