公开(公告)号：US20160215280A1

公开(公告)日：2016-07-28

申请号：US14916338

申请日：2014-09-04

Applicant: CSIR

Inventor： Stephanie FANUCCHI ,  Youtaro SHIBAYAMA ,  Shaun BURD ,  Musa M. MHLANGA

IPC: C12N15/01 ,  C12Q1/68

CPC classification number: C12N15/01 ,  C12N9/22 ,  C12N15/63 ,  C12Q1/6841 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: This invention relates to a single cell assay for determining the effect of chromosomal contact on the transcriptional activity of genes of interest in a cell and to methods of silencing gene expression in a cell by way of perturbing gene regulatory elements which are engaged in chromosomal contact.

Abstract translation: 本发明涉及用于确定染色体接触对细胞中感兴趣的基因的转录活性的影响的单细胞测定法，以及通过干扰参与染色体接触的基因调控元件沉默细胞中基因表达的方法。

公开(公告)号：US20190338280A1

公开(公告)日：2019-11-07

申请号：US16220270

申请日：2018-12-14

Applicant: CSIR

Inventor： Emiliano DALLA ,  Musa M. MHLANGA ,  Stephanie FANUCCHI ,  Youtaro SHIBAYAMA

IPC: C12N15/113 ,  C12N7/00

Abstract: The present invention relates to methods for modulating the production of ELR+ proinflammatory chemokines in a subject or a cell using either UMLILO IncRNA inhibitors to decrease production of ELR+ proinflammatory cytokines or using UMLILO IncRNA's to increase the production of ELR+ proinflammatory cytokines. The invention also provides for the use of UMLILO IncRNA inhibitors or UMLILO IncRNA's to modulate the expression of ERL+ proinflammatory cytokines.

公开(公告)号：US20190112592A1

公开(公告)日：2019-04-18

申请号：US16195240

申请日：2018-11-19

Applicant: CSIR

Inventor： Stephanie FANUCCHI ,  Youtaro SHIBAYAMA ,  Shaun BURD ,  Musa M. MHLANGA

IPC: C12N15/01 ,  C12Q1/6876 ,  C12N15/63 ,  C12N9/22 ,  C12Q1/6841

Abstract: This invention relates to a single cell assay for determining the effect of chromosomal contact on the transcriptional activity of genes of interest in a cell and to methods of silencing gene expression in a cell by way of perturbing gene regulatory elements which are engaged in chromosomal contact.