公开(公告)号：US20220152087A1

公开(公告)日：2022-05-19

申请号：US17097977

申请日：2020-11-13

Applicant: CYCLOLAB CYCLODEXTRIN RESEARCH AND DEVELOPMENT LABORATORY LTD.

Inventor： Tamas Sohajda ,  Istvan Puskas ,  Eva Harris ,  Francielle Tramontini Gomes de Sousa ,  Robert Beatty ,  Peter Laing

IPC: A61K31/724 ,  A61P9/10

Abstract: The present invention generally relates to cyclodextrin derivatives, including Dexolve®, sulfobutylether beta cyclodextrin interfering with the activity of the viral nonstructural protein NS1 produced by a flavivirus. More particularly, the present invention relates to method of treatment using cyclodextrin compounds for inhibiting or treating a condition resulting from a flavivirus infection, particularly vascular leakage condition and increased virus dissemination.