-
公开(公告)号:US20230146923A1
公开(公告)日:2023-05-11
申请号:US17982901
申请日:2022-11-08
Applicant: California Institute of Technology
Inventor: Tsui-Fen Chou , Shan Li , Feng Wang , Nadia Houerbi
IPC: C12Q1/6886 , C12N15/113 , C07K16/40 , C12N9/22 , A61P35/00
CPC classification number: C12Q1/6886 , C12N15/1137 , C07K16/40 , C12N9/22 , A61P35/00
Abstract: Provided herein are methods and compositions for inhibiting p97, for the treatment of a cancer in a subject, or a symptom thereof. Upon treatment, the cancer, or a symptom thereof is reduced in the subject. Additionally, methods for measuring sensitivity of a subject to p97 inhibition, methods of assessing a pharmaceutical agent for p97 inhibition activity, and methods of assessing the effect of a pharmaceutical agent for p97 inhibition activity in a subject are provided herein.
-
公开(公告)号:US20230012420A1
公开(公告)日:2023-01-12
申请号:US17849075
申请日:2022-06-24
Applicant: California Institute of Technology
Inventor: Tsui-Fen Chou , Shan Li , Feng Wang , Ting-Yu Wang
IPC: C12N15/113 , A61K31/7088 , A61K38/46 , A61K31/519 , A61K31/4439 , A61K31/428 , A61K31/517 , A61K31/4045 , A61K31/69 , A61K31/538 , A61K31/496 , C07K16/40 , A61P25/28 , C12Q1/6883
Abstract: Provided herein are methods and compositions for inhibiting p97, for the treatment of a motor neuron disease in a subject, or a symptom thereof. Upon treatment, the motor neuron disease, or a symptom thereof is reduced in the subject.
-
公开(公告)号:US20230002774A1
公开(公告)日:2023-01-05
申请号:US17849132
申请日:2022-06-24
Applicant: California Institute of Technology
Inventor: Kai-Wen Cheng , Shan Li , Feng Wang , Tsui-Fen Chou
IPC: C12N15/113 , C07K16/40 , A61K38/46 , A61K31/7088 , A61K31/519 , A61K31/4439 , A61K31/517 , A61K31/403 , A61K31/538 , A61K31/496 , A61P31/14
Abstract: Provided herein are methods and compositions for inhibiting p97, for the treatment of a coronavirus infection in a subject, or a symptom thereof. Upon treatment, the coronavirus infection, or a symptom thereof is reduced in the subject.
-
-