公开(公告)号：US20240139329A1

公开(公告)日：2024-05-02

申请号：US18495508

申请日：2023-10-26

Applicant: California Institute of Technology

Inventor： Viviana Gradinaru ,  Timothy F. Shay ,  Xinhong Chen ,  Seongmin Jang

IPC: A61K47/64 ,  A61K48/00 ,  C07K14/00

CPC classification number: A61K47/64 ,  A61K48/0041 ,  C07K14/001

Abstract: Disclosed herein include novel blood-brain barrier (BBB)-crossing receptors on the BBB interface, targeting peptides and derivatives thereof capable of binding to the novel receptors, and related methods of using the receptors to increase the permeability of the BBB and to deliver an agent to a nervous system (e.g., CNS). In some embodiments, the BBB-crossing receptor is LRP6. Disclosed herein also include recombinant adeno-associated viruses (rAAVs) with increased specificity and transduction efficiency across the BBB and related compositions and methods of treating various diseases and conditions.