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1.发明公开公开(公告)号：US20240132861A1
公开(公告)日：2024-04-25
申请号：US18333344
申请日：2023-06-11
Applicant: California Institute of Technology
Inventor： Yuki Oka , Allan-Hermann Pool
CPC classification number: C12N9/22 , A61K9/0043 , A61K35/12 , A61K48/005 , C12N15/11 , C12N15/86 , C12N15/90 , A61K38/00 , C12N2750/14143 , C12N2800/80
Abstract: Disclosed herein include methods and compositions for incorporating an effector gene into the genome of a cell. The method can comprise introducing into a cell a donor nucleic acid comprising a recognition site, a splice acceptor site, a self-cleaving peptide sequence, an effector gene, and an optional transcript stabilization element. The donor nucleic acid can be incorporated into the intron of a target gene differentially expressed in a unique cell type and/or in a cell during a unique cell state via non-homologous end joining (NHEJ)-dependent DNA repair. There are also provided, in some embodiments, methods and compositions for treating a disease or disorder in a subject.
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2.发明授权公开(公告)号：US12152260B2
公开(公告)日：2024-11-26
申请号：US18333344
申请日：2023-06-12
Applicant: California Institute of Technology
Inventor： Yuki Oka , Allan-Hermann Pool
IPC: C12N9/22 , A61K9/00 , A61K35/12 , A61K38/00 , A61K48/00 , A61P25/04 , A61P25/28 , C12N15/11 , C12N15/86 , C12N15/90
Abstract: Disclosed herein include methods and compositions for incorporating an effector gene into the genome of a cell. The method can comprise introducing into a cell a donor nucleic acid comprising a recognition site, a splice acceptor site, a self-cleaving peptide sequence, an effector gene, and an optional transcript stabilization element. The donor nucleic acid can be incorporated into the intron of a target gene differentially expressed in a unique cell type and/or in a cell during a unique cell state via non-homologous end joining (NHEJ)-dependent DNA repair. There are also provided, in some embodiments, methods and compositions for treating a disease or disorder in a subject.
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公开(公告)号：US20240238370A1
公开(公告)日：2024-07-18
申请号：US18431197
申请日：2024-02-02
Applicant: California Institute of Technology
Inventor： Yuki Oka , Sangjun Lee
CPC classification number: A61K38/1709 , A61K9/0019 , C12N15/86 , C12N2750/14143
Abstract: Disclosed herein include methods and compositions for modulating sodium appetite and/or intake. In some embodiments, the sodium appetite of a subject is reduced. Also disclosed include methods for identifying modulators for sodium appetite and/or intake.
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公开(公告)号：US20200222500A1
公开(公告)日：2020-07-16
申请号：US16738380
申请日：2020-01-09
Applicant: California Institute of Technology
Inventor： Yuki Oka , Sangjun Lee
Abstract: Disclosed herein include methods and compositions for modulating sodium appetite and/or intake. In some embodiments, the sodium appetite of a subject is reduced. Also disclosed include methods for identifying modulators for sodium appetite and/or intake.
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公开(公告)号：US20190216948A1
公开(公告)日：2019-07-18
申请号：US16245801
申请日：2019-01-11
Applicant: California Institute of Technology
Inventor： Yuki Oka , Vineet Augustine
CPC classification number: A61K48/005 , A61K31/5513 , A61K38/1787 , A61P13/12 , A61P43/00 , C12N7/00 , C12N15/86 , C12Y114/13039
Abstract: In some embodiments, methods of stimulating fluid intake in a subject in need thereof are described. The methods can comprise stimulating a nitric oxide synthase (nNOS)-positive neuron of the median preoptic nucleus (MnPO). In some embodiments, methods of inhibiting fluid intake in a subject in need thereof are described. The methods can comprise inhibiting stimulation of an nNOS-positive neuron of the MnPO.
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Patent Agency Ranking
公开(公告)号：US20250152602A1
公开(公告)日：2025-05-15
申请号：US18948540
申请日：2024-11-15
Applicant: California Institute of Technology
Inventor： Yuki Oka , Yameng Zhang
IPC: A61K31/5513 , A61K31/192 , A61K31/60 , A61P27/00 , C12N15/113 , G01N33/50
Abstract: Disclosed herein include methods and compositions suitable for use in modulation of aversive taste tolerance. In some embodiments, ingestion of sodium and/or aversive substances is reduced. Also disclosed include methods for identifying modulators for aversive taste tolerance.
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7.发明公开公开(公告)号：US20240228991A9
公开(公告)日：2024-07-11
申请号：US18333344
申请日：2023-06-12
Applicant: California Institute of Technology
Inventor： Yuki Oka , Allan-Hermann Pool
CPC classification number: C12N9/22 , A61K9/0043 , A61K35/12 , A61K48/005 , C12N15/11 , C12N15/86 , C12N15/90 , A61K38/00 , C12N2750/14143 , C12N2800/80
Abstract: Disclosed herein include methods and compositions for incorporating an effector gene into the genome of a cell. The method can comprise introducing into a cell a donor nucleic acid comprising a recognition site, a splice acceptor site, a self-cleaving peptide sequence, an effector gene, and an optional transcript stabilization element. The donor nucleic acid can be incorporated into the intron of a target gene differentially expressed in a unique cell type and/or in a cell during a unique cell state via non-homologous end joining (NHEJ)-dependent DNA repair. There are also provided, in some embodiments, methods and compositions for treating a disease or disorder in a subject.
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公开(公告)号：US10960084B2
公开(公告)日：2021-03-30
申请号：US16245801
申请日：2019-01-11
Applicant: California Institute of Technology
Inventor： Yuki Oka , Vineet Augustine
Abstract: In some embodiments, methods of stimulating fluid intake in a subject in need thereof are described. The methods can comprise stimulating a nitric oxide synthase (nNOS)-positive neuron of the median preoptic nucleus (MnPO). In some embodiments, methods of inhibiting fluid intake in a subject in need thereof are described. The methods can comprise inhibiting stimulation of an nNOS-positive neuron of the MnPO.
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公开(公告)号：US11890318B2
公开(公告)日：2024-02-06
申请号：US16738380
申请日：2020-01-09
Applicant: California Institute of Technology
Inventor： Yuki Oka , Sangjun Lee
CPC classification number: A61K38/1709 , A61K9/0019 , C12N15/86 , C12N2750/14143
Abstract: Disclosed herein include methods and compositions for modulating sodium appetite and/or intake. In some embodiments, the sodium appetite of a subject is reduced. Also disclosed include methods for identifying modulators for sodium appetite and/or intake.
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10.发明授权公开(公告)号：US11702644B2
公开(公告)日：2023-07-18
申请号：US16845009
申请日：2020-04-09
Applicant: California Institute of Technology
Inventor： Yuki Oka , Allan-Hermann Pool
IPC: C12N9/22 , A61K9/00 , A61K35/12 , A61K48/00 , C12N15/11 , C12N15/86 , C12N15/90 , A61K38/00 , A61P25/04 , A61P25/28
CPC classification number: C12N9/22 , A61K9/0043 , A61K35/12 , A61K48/005 , C12N15/11 , C12N15/86 , C12N15/90 , A61K38/00 , C12N2310/20 , C12N2750/14143 , C12N2800/80
Abstract: Disclosed herein include methods and compositions for incorporating an effector gene into the genome of a cell. The method can comprise introducing into a cell a donor nucleic acid comprising a recognition site, a splice acceptor site, a self-cleaving peptide sequence, an effector gene, and an optional transcript stabilization element. The donor nucleic acid can be incorporated into the intron of a target gene differentially expressed in a unique cell type and/or in a cell during a unique cell state via non-homologous end joining (NHEJ)-dependent DNA repair. There are also provided, in some embodiments, methods and compositions for treating a disease or disorder in a subject.
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