公开(公告)号：US20140093147A1

公开(公告)日：2014-04-03

申请号：US13998776

申请日：2013-12-03

Applicant: Chemlmage Corporation

Inventor： Shona Stewart ,  Patrick Treado ,  Heather Kirschner ,  Alan Wilson ,  Ryan Priore ,  Jeffrey Cohen ,  Serena Augustine

IPC: G01N21/25

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/32 ,  G01J3/44 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample.

Abstract translation: 一种使用高光谱成像分析器官样品的方法，包括照亮器官样品以产生相互作用的光子，收集相互作用的光子并使相互作用的光子通过可调滤光器。 检测过滤的相互作用的光子以产生高光谱图像。 生成亮场图像并与高光谱图像相关联。 提取并分析来自感兴趣位置的光谱，以评估器官样品的特征。 系统可以包括用于照亮器官样本并产生相互作用的光子的照明源，用于收集相互作用的光子的收集光学器件和用于过滤相互作用的光子的可调滤波器。 检测器被配置为检测滤波的光子并产生至少一个高光谱图像。 检测器还可以被配置为产生代表器官样本的至少一个亮场图像。

公开(公告)号：US20140198315A1

公开(公告)日：2014-07-17

申请号：US14155883

申请日：2014-01-15

Applicant: Chemlmage Corporation

Inventor： Ryan Priore ,  Patrick Treado ,  Matthew Nelson

IPC: G01J3/51

CPC classification number: G01J3/32 ,  G01J3/0224 ,  G01J3/36 ,  G01J3/457 ,  G01J2003/1213 ,  G01N21/31

Abstract: A system and method for detecting at least one target of interest using at least two conformal filters in a dual polarization configuration. A plurality of interacted photons are collected from a sample comprising at least one analyte of interest. The plurality of interacted photons are separated into at least a first and second optical component. The first optical component is passed through a first conformal filter and the second optical component is passed through a second conformal filter. A Data set corresponding to each filtered optical component is generated and an optical computation is applied to assess at least one characteristic of the analyte.

Abstract translation: 一种用于在双极化配置中使用至少两个共形滤波器来检测至少一个感兴趣的目标的系统和方法。 从包含至少一种目的分析物的样品收集多个相互作用的光子。 多个相互作用的光子被分成至少第一和第二光学部件。 第一光学部件通过第一保形过滤器，并且第二光学部件通过第二适形过滤器。 生成对应于每个滤波的光学部件的数据集，并应用光学计算来评估分析物的至少一个特性。