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    ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES
    1.
    发明申请
    ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US20110251093A1

    公开(公告)日：2011-10-13

    申请号：US13084869

    申请日：2011-04-12

    Applicant: Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    Inventor： Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    IPC: C40B30/04

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    Analysis, secure access to, and transmission of array images
    2.
    发明授权
    Analysis, secure access to, and transmission of array images 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US07940968B2

    公开(公告)日：2011-05-10

    申请号：US11439599

    申请日：2006-05-23

    Applicant: Michael Seul ,  Xiongwu Xia ,  Chiu Chau

    Inventor： Michael Seul ,  Xiongwu Xia ,  Chiu Chau

    IPC: G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    PROBE DENSITY SELF-CONSIDERATIONS AND ELONGATION OF COMPLEMENTARY LOOPED PROBES WHERE PROBES ARE ATTACHED TO A SOLID PHASE
    3.
    发明申请
    PROBE DENSITY SELF-CONSIDERATIONS AND ELONGATION OF COMPLEMENTARY LOOPED PROBES WHERE PROBES ARE ATTACHED TO A SOLID PHASE 有权
    探索密度自我考虑和延伸的复杂循环探测器，其中探测器连接到固相

    公开(公告)号：US20100267578A1

    公开(公告)日：2010-10-21

    申请号：US12708362

    申请日：2010-02-18

    Applicant: MICHAEL SEUL ,  Yi Zhang ,  Sukanta Banerjee ,  Jiacheng Yang ,  Chiu Chau

    Inventor： MICHAEL SEUL ,  Yi Zhang ,  Sukanta Banerjee ,  Jiacheng Yang ,  Chiu Chau

    IPC: C40B30/04

    CPC classification number: C12Q1/6837 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q2565/1015 ,  C12Q2537/143 ,  C12Q2533/101 ,  C12Q2535/125 ,  C12Q2525/301

    Abstract: In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps:adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.

    Abstract translation: 在溶液中进行的多重测定方法中，其中溶液含有核酸靶，并且其中使用几个不同类型的寡核苷酸探针，每个类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸 目标，所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加有效 通过一种或多种以下方法可用于结合探针的靶的浓度：（i）在珠的表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

    Solid Phase Nucleic Acid Extraction From Leukoreduced Blood
    4.
    发明申请
    Solid Phase Nucleic Acid Extraction From Leukoreduced Blood 审中-公开
    白血病中的固相核酸提取

    公开(公告)号：US20110223589A1

    公开(公告)日：2011-09-15

    申请号：US13019511

    申请日：2011-02-02

    Applicant: Chiu Chau

    Inventor： Chiu Chau

    IPC: C12Q1/68

    CPC classification number: C12N15/1013

    Abstract: Products for and a method of capturing and storing nucleic acid from leukoreduced patient blood, where the products capture sufficient quantities for use in PCR and analysis of nucleic acid, are described. The products are made by heating a mixture of magnetic beads, silica particles, alkyl silicate (e.g., Silbond 4, Silbond Corp., Weston, Mich.) and polyethylene resin particles. The quantity of nucleic acid adsorbed by the product is controlled by the surface area of silica available for binding to nucleic acid, which in turn is controlled by: the overall volume of the product, the ratio of the volume of polyethylene resin particles to the volumes of silica particles and alkyl silicate; and the sizes of silica particles (smaller particles have a larger surface area per unit volume).

    Abstract translation: 描述了捕获和存储来自白细胞减少的患者血液的核酸的产物和方法，其中产物捕获足够的量用于PCR和分析核酸。 产物通过加热磁珠，二氧化硅颗粒，硅酸烷基酯（例如，Silbond 4，Silbond Corp.，Weston，Mich。）和聚乙烯树脂颗粒的混合物制成。 产物吸附的核酸的量由可用于与核酸结合的二氧化硅的表面积控制，二氧化硅的结合面依次为：产品的总体积，聚乙烯树脂颗粒体积与体积的比例 二氧化硅颗粒和硅酸烷基酯; 并且二氧化硅颗粒的尺寸（较小的颗粒具有较大的每单位体积的表面积）。

    Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase
    5.
    发明申请
    Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase 审中-公开
    探头密度考虑和探针附着在固相上的自互补环状探针的伸长率

    公开(公告)号：US20070243534A1

    公开(公告)日：2007-10-18

    申请号：US11403100

    申请日：2006-04-12

    Applicant: Michael Seul ,  Yi Zhang ,  Sukanta Banerjee ,  Jiacheng Yang ,  Chiu Chau

    Inventor： Michael Seul ,  Yi Zhang ,  Sukanta Banerjee ,  Jiacheng Yang ,  Chiu Chau

    IPC: C12Q1/68 ,  C12M3/00

    CPC classification number: C12Q1/6837 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q2565/1015 ,  C12Q2537/143 ,  C12Q2533/101 ,  C12Q2535/125 ,  C12Q2525/301

    Abstract: In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps: adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.

    Abstract translation: 在溶液中进行的多重测定方法中，其中溶液含有核酸靶，并且其中使用几个不同类型的寡核苷酸探针，每个类型在被称为靶结合结构域的区域中具有不同序列，以检测核酸 目标，所述测定方法包括通过一个或多个以下步骤增加寡核苷酸探针结合珠粒表面上的核酸靶的有效浓度的方法：调节测定条件以增加有效 通过一种或多种以下方法可用于结合探针的靶的浓度：（i）在珠的表面上选择特定的探针密度; （ii）选择具有大于阈值的离子强度的溶液; （ii）选择小于阈值的大小的目标域; 或（iii）在目标的终端的指定接近范围内选择目标域。

    Number coding for identification of subtypes of coded types of solid phase carriers
    7.
    发明申请
    Number coding for identification of subtypes of coded types of solid phase carriers 有权
    用于识别编码类型的固相载体亚型的编号

    公开(公告)号：US20050288870A1

    公开(公告)日：2005-12-29

    申请号：US10943760

    申请日：2004-09-17

    Applicant: Michael Seul ,  Enqing Tan ,  Chiu Chau

    Inventor： Michael Seul ,  Enqing Tan ,  Chiu Chau

    IPC: C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  H03M20060101 ,  G06F19/00

    CPC classification number: G01N33/6845 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/564

    Abstract: Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a C-code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, in multiplexed nucleic acid or protein analysis.

    Abstract translation: 公开了固相载波的对（“双”）或小集（“多重”）的数字编码提供了给定类型的这种载波的可区分的子类型，其中每个载波类型基于C码可区分。 这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。 它可以应用于例如多重核酸或蛋白质分析中。

    Number coding for identification of subtypes of coded types of solid phase carriers
    8.
    发明授权
    Number coding for identification of subtypes of coded types of solid phase carriers 有权
    用于识别编码类型的固相载体亚型的编号

    公开(公告)号：US07927796B2

    公开(公告)日：2011-04-19

    申请号：US10943760

    申请日：2004-09-17

    Applicant: Michael Seul ,  Enqing Tan ,  Chiu Chau

    Inventor： Michael Seul ,  Enqing Tan ,  Chiu Chau

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04 ,  G01N33/543 ,  G01N15/06 ,  G01N33/48

    CPC classification number: G01N33/6845 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/564

    Abstract: Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the basis of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.

    Abstract translation: 披露了提供给定类型的这种载体的可区分子类型的固相载体的对（“双”）或小集（“多重”）的数字编码，其中每种载体类型基于不同的代码可区分。 这种数字编码对于增加诸如颜色代码的编码系统是有用的，从而有效地乘以“颜色”的数量（可区分的子类型）。 例如，它可以应用于确定样品在两个不同等位基因之一的多个不同位点是纯合的还是杂合的，其中针对两个等位基因中的每一个应用相同的颜色代码，并且具有相同的等位基因 通过知道多少载体与检测每​​个不同等位基因的分子相关联来区分颜色代码。

    Analysis, secure access to, and transmission of array images
    9.
    发明授权
    Analysis, secure access to, and transmission of array images 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US07526114B2

    公开(公告)日：2009-04-28

    申请号：US10714203

    申请日：2003-11-14

    Applicant: Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    Inventor： Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    IPC: G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

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