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公开(公告)号：US09162009B2
公开(公告)日：2015-10-20
申请号：US14064354
申请日：2013-10-28
Applicant: Cochlear Limited
Inventor： Jane Rapsey , Martin Svehla , Peter Schuller , Christopher Robert Miller
CPC classification number: A61L27/20 , A61F11/00 , A61F2250/0067 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/602 , A61L2430/14 , A61N1/0541 , A61N1/36032 , A61N1/36036 , C08L83/04
Abstract: Implantable drug-doped component, e.g., a cochlear implant, including host material, a host-embedded drug, a sacrificial material integrated with the host. Sacrificial material facilitates release of drug from the component. Sacrificial material facilitates release through creation of voids in the host upon dissolution of sacrificial material upon contact with a solvent, e.g., perilymph fluid upon implant. Host can be polysiloxane, or silicone rubber. Drug can be anti-inflammatory, growth factor, antibody, anti-oxidant, antibiotic, corticosteroid. Sacrificial material can be: glucose monomer, sugar, cyclodextrin, dissolvable or resorbable at implant site, a salt, bioresorbable material, hyaluronic acid, polyurethane, polyester, polyamide, polyvinyl alcohol, polyacrylic acid. Sacrificial material can be the host, and can facilitate release of drug through changing a property of sacrificial material, e.g., by exposing component to ethanol wash. For a cochlear implant, drug doped material can be applied to a non-stimulating surface of the electrode array, and can be a physical feature of stimulating medical device, e.g., soft tip, ridge, spine. For a cochlear implant the drug-doped material can excluded from the basal side of the most basal electrode contact.
Abstract translation: 可植入药物掺杂组分，例如耳蜗植入物，包括宿主材料，宿主植入药物，与宿主整合的牺牲材料。 牺牲物质有助于药物从组分中的释放。 牺牲材料通过在与溶剂（例如植入物上的外淋巴液）接触时溶解牺牲材料时在主体中产生空隙来促进释放。 主体可以是聚硅氧烷或硅橡胶。 药物可以是抗炎，生长因子，抗体，抗氧化剂，抗生素，皮质类固醇。 牺牲材料可以是：葡萄糖单体，糖，环糊精，在植入部位可溶或可吸收，盐，生物可再吸收材料，透明质酸，聚氨酯，聚酯，聚酰胺，聚乙烯醇，聚丙烯酸。 牺牲材料可以是宿主，并且可以通过改变牺牲材料的性质来促进药物的释放，例如通过将组分暴露于乙醇洗涤液中。 对于耳蜗植入物，药物掺杂材料可以施加到电极阵列的非刺激表面，并且可以是刺激医疗装置的物理特征，例如软尖端，脊脊，脊柱。 对于耳蜗植入物，药物掺杂材料可以从最基底的电极接触的基底侧排除。
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公开(公告)号：US09694174B2
公开(公告)日：2017-07-04
申请号：US14622130
申请日：2015-02-13
Applicant: Cochlear Limited
Inventor： Fysh Dadd , Andy Ho , Shahram Manouchehri , Nicholas Charles Kendall Pawsey , Peter Schuller , Peter Raymond Sibary
CPC classification number: A61N1/0541 , H01R43/02 , Y10T29/49002 , Y10T29/49005 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49211
Abstract: A method of forming an electrode array is disclosed, the method comprising: forming an elongate comb structure comprising a plurality of longitudinally-spaced electrode contacts extending from and supported by a spine; electrically connecting each of a plurality of electrically conductive pathways to a respective one of the plurality of electrode contacts; placing the conductive pathways adjacent the contacts; placing silicone over the conductive pathways and contacts; curing the silicone so as to substantially retain the longitudinal spacing between neighboring contacts; and severing the spine from the plurality of electrode contacts.
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公开(公告)号：US11058871B2
公开(公告)日：2021-07-13
申请号：US15639125
申请日：2017-06-30
Applicant: Cochlear Limited
Inventor： Fysh Dadd , Andy Ho , Shahram Manouchehri , Nicholas Charles Kendall Pawsey , Peter Schuller , Peter Raymond Sibary
Abstract: A method of forming an electrode array is disclosed, the method comprising: forming an elongate comb structure comprising a plurality of longitudinally-spaced electrode contacts extending from and supported by a spine; electrically connecting each of a plurality of electrically conductive pathways to a respective one of the plurality of electrode contacts; placing the conductive pathways adjacent the contacts; placing silicone over the conductive pathways and contacts; curing the silicone so as to substantially retain the longitudinal spacing between neighboring contacts; and severing the spine from the plurality of electrode contacts.
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