公开(公告)号：US20180244841A1

公开(公告)日：2018-08-30

申请号：US15756670

申请日：2016-09-02

Applicant: Colorado State University Research Foundation

Inventor： Eugene Y. CHEN ,  Jian-Bo ZHU

IPC: C08G63/82 ,  C08G63/08 ,  C08L67/04 ,  C07D405/04 ,  C07D515/08

CPC classification number: C08G63/823 ,  C07D405/04 ,  C07D515/08 ,  C08G63/08 ,  C08L67/04 ,  C08L2207/10

Abstract: B/N Lewis pairs have been discovered to catalyze rapid epimerization of meso-lactide (LA) or LA diastereomers quantitatively into rac-LA. The obtained rac-LA can be kinetically polymerized into poly(L-lactide) and optically resolved D-LA, with a high stereoselectivity factor kL/kD of 53 and an ee value of 91% at 50.6% monomer conversion, by a bifunctional chiral catalyst. The epimerization and enantioselective polymerization can be coupled into a one-pot process for transforming meso-LA directly into poly(L-lactide) and D-LA.