公开(公告)号：US20230294093A1

公开(公告)日：2023-09-21

申请号：US18186597

申请日：2023-03-20

Applicant: Colorado State University Research Foundation

Inventor： Thomas Chen ,  Nicholas Grant

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2300/0636 ,  B01L2300/087 ,  B01L2400/06 ,  B01L2400/043 ,  B01L2400/0496 ,  B01L2200/16

Abstract: An exemplary system and method are disclosed for a digital microfluidic chip cartridge and system configured for electro-wetting on dielectric (EWOD) microfluidic operations and experimental analysis. The exemplary portable lab-on-a-chip devices and systems can be configured to execute complex assays such as DNA isolation employing integrated sensor and electronics can analyze results. The EWOD or digital microfluidic cartridge can be configured with customizable assays having preloaded reagents targeted specifically for a given assay that can be used in an analysis in the field (i.e., point of care, i.e., not in a central laboratory) using a disposable or recyclable assay cartridge system. The cartridge and portable instrument can operate on specific instructions based on the algorithm intended for the assay.

公开(公告)号：US20230117156A1

公开(公告)日：2023-04-20

申请号：US17965989

申请日：2022-10-14

Applicant: Colorado State University Research Foundation

Inventor： Thomas Chen

IPC: C12M1/34 ,  G01N27/416 ,  C12M1/26 ,  C12M1/00

Abstract: Electrochemical sensing devices and methods of using thereof employs a set of one or more sensor-integrated sampling wells or containers that operates with a pressure differential micro-valve to move controlled volume of sampled fluid within a controlled cell-growing environment. The differential micro-valve can be integrated into an instrumented well having one or more sensors to provide a high-throughput smart well plate platform for use in automation operation in diagnostics and drug discovery.