公开(公告)号：US20250163040A1

公开(公告)日：2025-05-22

申请号：US18779607

申请日：2024-07-22

Applicant: Cornell University

Inventor： John W. BABICH ,  Justin WILSON ,  Nikki THIELE ,  James KELLY ,  Shashikanth PONNALA

IPC: C07D413/14 ,  A61K45/06 ,  A61K51/04 ,  A61K51/10 ,  C07B59/00

Abstract: The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed.

公开(公告)号：US20220177461A1

公开(公告)日：2022-06-09

申请号：US17678793

申请日：2022-02-23

Applicant: Cornell University

Inventor： John W. Babich ,  Justin WILSON ,  Nikki THIELE ,  James KELLY ,  Shashikanth PONNALA

IPC: C07D413/14 ,  A61K51/04 ,  A61K51/10

Abstract: The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed.