公开(公告)号：US20250092067A1

公开(公告)日：2025-03-20

申请号：US18562243

申请日：2022-05-19

Applicant: Cornell University

Inventor： Hening Lin ,  Kevin Wielenberg ,  Min Yang

IPC: C07F5/02 ,  A61K31/496 ,  A61K31/675 ,  A61K31/69 ,  C07D409/06 ,  C07D495/04 ,  C07F9/6509 ,  C07F9/6558

Abstract: Compounds, compositions including one or more of the compound(s), and methods of using the compounds and the compositions. The compounds comprise an (I) group. In various examples, a compound is an Acyl Protein Thioesterase 1 inhibitor (APT1 inhibitor) and/or an Acyl Protein Thioesterase 2 inhibitor (APT2 inhibitor). Compound(s) or composition(s), which may be pharmaceutical composition(s), can be used in methods of treating diseases or disorders, such as, for example, autoimmune disorders, neurodegenerative disorders, inflammatory disorders, and immune-mediated cancer diseases.