公开(公告)号：US20240159770A1

公开(公告)日：2024-05-16

申请号：US18420570

申请日：2024-01-23

Applicant: Cowper Sciences Inc.

Inventor： Matthew GREVING ,  David SMITH ,  Gaurav SAINI

IPC: G01N33/68 ,  A61K39/395 ,  B01J19/00 ,  C07K16/32 ,  C12N15/10

CPC classification number: G01N33/6845 ,  A61K39/395 ,  A61K39/39558 ,  B01J19/0046 ,  C07K16/32 ,  C12N15/1055 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00725 ,  C07K2317/34 ,  C07K2317/92

Abstract: Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins.

公开(公告)号：US20240077492A1

公开(公告)日：2024-03-07

申请号：US17822757

申请日：2022-08-26

Applicant: Cowper Sciences Inc.

Inventor： Matthew GREVING ,  David SMITH ,  Gaurav SAINI

IPC: G01N33/68 ,  B01J19/00 ,  C07K16/32 ,  C12N15/10

CPC classification number: G01N33/6845 ,  B01J19/0046 ,  C07K16/32 ,  C12N15/1055 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00725 ,  C07K2317/34 ,  C07K2317/92

Abstract: Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins.

公开(公告)号：US20220010301A1

公开(公告)日：2022-01-13

申请号：US17294345

申请日：2019-11-13

Applicant: Cowper Sciences Inc.

Inventor： Mohan SRINIVASAN ,  Matthew GREVING

IPC: C12N15/10 ,  C07K7/06 ,  C07K7/08

Abstract: Provided herein are functional interface mimics (FIMs), which mimic a functional interface of an interface protein. The FIMs comprise at least one peptide and at least one linking moiety, such as a linker or a cross-link. In some embodiments, the FIMs comprise at least two peptides connected by at least one linker. In some embodiments, the FIM is an immunogen. Also provided herein are methods of selected an FIM, and methods of producing an antibody using an FIM.