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公开(公告)号:US11027250B2
公开(公告)日:2021-06-08
申请号:US16328129
申请日:2017-09-04
Applicant: Cytiva BioProcess R&D AB
Inventor: Jimmy Hedin Dahlstrom , Jonas Bengtsson , Per Erik Emilsson , Maranda Fordham , Eva Holmgren , Ronnie Palmgren , Fernando Polanco
Abstract: A system and method for producing fine droplets of polysaccharide from a premixed water-in-oil emulsion uses a packed bed (5) comprising hydrophilic beads (7).
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公开(公告)号:US20220106462A1
公开(公告)日:2022-04-07
申请号:US17550830
申请日:2021-12-14
Applicant: Cytiva BioProcess R&D AB
Inventor: Per Erik Emilsson , Susanna Klara Margareta Lindberg , Jonny Wernersson , Jonas Gustafsson , Adam Hurynowicz
Abstract: The invention discloses a method of manufacturing polysaccharide beads, comprising the steps of: i) providing a water phase comprising an aqueous solution of a polysaccharide; ii) providing an oil phase comprising at least one water-immiscible organic solvent and at least one oil-soluble emulsifier; iii) emulsifying the water phase in the oil phase to form a water-in-oil (w/o) emulsion; and iv) inducing solidification of the water phase in the w/o emulsion, wherein the organic solvent is an aliphatic or alicyclic ketone or ether.
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公开(公告)号:US11236216B2
公开(公告)日:2022-02-01
申请号:US15578074
申请日:2016-05-27
Applicant: Cytiva BioProcess R&D AB
Inventor: Per Erik Emilsson , Susanna Klara Margareta Lindberg , Jonny Wernersson , Jonas Gustafsson , Adam Hurynowicz
Abstract: The invention discloses a method of manufacturing polysaccharide beads, comprising the steps of: i) providing a water phase comprising an aqueous solution of a polysaccharide; ii) providing an oil phase comprising at least one water-immiscible organic solvent and at least one oil-soluble emulsifier; iii) emulsifying the water phase in the oil phase to form a water-in-oil (w/o) emulsion; and iv) inducing solidification of the water phase in the w/o emulsion, wherein the organic solvent is an aliphatic or alicyclic ketone or ether.
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