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公开(公告)号：US20230073652A1
公开(公告)日：2023-03-09
申请号：US17873248
申请日：2022-07-26
Applicant: DALIAN UNIVERSITY OF TECHNOLOGY
Inventor： Xinfu ZHANG , Yi XIAO , Xiangli LI
IPC: C07D517/14 , C07D209/58
Abstract: The present disclosure relates to Near-infrared fluorescent indicators for lysosomes and application thereof. These indicators are composed of lipophilic NIR BODIPY derivatives and ionizable bis-tertiary amine moiety, which enable the formation of a transient amphiphilic state in acidic environments specifically. This structural feature affords accurate lysosomal membrane targeting ability at nanomole staining concentration.
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