公开(公告)号：US10127645B2

公开(公告)日：2018-11-13

申请号：US15752821

申请日：2016-08-11

Applicant: DIRECT GENOMICS CO., LTD.

Inventor： Liangjin Ge ,  Jianming Zeng ,  Qin Yan

IPC: G06K9/00 ,  G06T5/50 ,  G06F17/16 ,  G06T7/37

Abstract: An embodiment of the present disclosure discloses a method and a device of correcting a single-molecule image, the method includes: acquiring the first target simplified matrix corresponding to the first image according to the intensity matrix corresponding to each of pixels in the first image, and acquiring the second target simplified matrix corresponding to the second image according to the intensity matrix corresponding to each of the pixels in the second image; the two-dimensional DFT is performed to the first target simplified matrix and the second target simplified matrix respectively to acquire the first Fourier matrix corresponding to the first target simplified matrix and the second Fourier matrix corresponding to the second target simplified matrix; the method of correcting a single-molecule image acquire the offset of the second image with respect to the first image according to the first Fourier matrix and the second Fourier matrix; and correcting the second image according to the offset. Such method can correct the images of single molecules taken at different moments.

公开(公告)号：US20180240222A1

公开(公告)日：2018-08-23

申请号：US15752821

申请日：2016-08-11

Applicant: DIRECT GENOMICS CO., LTD.

Inventor： Liangjin Ge ,  Jianming Zeng ,  Qin Yan

IPC: G06T5/50 ,  G06T7/37 ,  G06F17/16

CPC classification number: G06T5/50 ,  G06F17/16 ,  G06T7/37

Abstract: An embodiment of the present disclosure discloses a method and a device of correcting a single-molecule image, the method includes: acquiring the first target simplified matrix corresponding to the first image according to the intensity matrix corresponding to each of pixels in the first image, and acquiring the second target simplified matrix corresponding to the second image according to the intensity matrix corresponding to each of the pixels in the second image; the two-dimensional DFT is performed to the first target simplified matrix and the second target simplified matrix respectively to acquire the first Fourier matrix corresponding to the first target simplified matrix and the second Fourier matrix corresponding to the second target simplified matrix; the method of correcting a single-molecule image acquire the offset of the second image with respect to the first image according to the first Fourier matrix and the second Fourier matrix; and correcting the second image according to the offset. Such method can correct the images of single molecules taken at different moments.