公开(公告)号：US20140037741A1

公开(公告)日：2014-02-06

申请号：US14052283

申请日：2013-10-11

Applicant: DSM IP ASSETS B.V.

Inventor： Steven ARMES ,  Jian-Jun YUAN

IPC: A61K9/50

CPC classification number: A61K9/5089 ,  A61K9/501 ,  C08K3/36 ,  C08K9/00 ,  C08K9/02 ,  C08K9/10 ,  C08K9/12 ,  C08K2201/011 ,  C08K2201/013 ,  C08L53/00 ,  C08L2207/53 ,  C09D7/70 ,  G02B1/111 ,  Y10T428/254 ,  Y10T428/2998

Abstract: Methods for the preparation of polymer-templated core-shell nanoparticles include the steps of (a) preparing a cationic polymeric core material comprising polymeric micelles, and (b) coating the core material with a silica-comprising shell by depositing the shell onto the polymeric micelles from at least one silica precursor to form the core-shell nanoparticles. Compositions which include the core-shell nanoparticles are adapted to facilitate controlled delivery of at least one active agent into a system in response to controlled changes in the pH of the system.

Abstract translation: 制备聚合物模板核 - 壳纳米颗粒的方法包括以下步骤：（a）制备包含聚合物胶束的阳离子聚合物芯材料，和（b）通过将壳体沉积到聚合物上涂覆含有二氧化硅的壳体， 从至少一个二氧化硅前体的胶束形成核 - 壳纳米颗粒。 包括核 - 壳纳米颗粒的组合物适于促进响应于系统pH的受控变化而将至少一种活性剂控制递送到系统中。

公开(公告)号：US20200230069A1

公开(公告)日：2020-07-23

申请号：US16842831

申请日：2020-04-08

Applicant: DSM IP Assets B.V.

Inventor： Nanning Joerg ARFSTEN ,  Steven ARMES ,  Pascal Jozef Paul BUSKENS ,  Jens Christoph THIES ,  Patrick Wilhelmus Antonius VRIJALDENHOVEN

IPC: A61K9/50 ,  C09D7/40 ,  C08K9/12 ,  G02B1/111 ,  C08K9/00

Abstract: Compositions suitable for forming an optical coating are provided, wherein the compositions include core-shell nanoparticles having (a) a core material which includes a polymer; and (b) a shell material which includes a metal oxide.

公开(公告)号：US20180078509A1

公开(公告)日：2018-03-22

申请号：US15826487

申请日：2017-11-29

Applicant: DSM IP ASSETS B.V.

Inventor： Nanning Joerg ARFSTEN ,  Steven ARMES ,  Pascal Jozef Paul BUSKENS ,  Jens Christoph THIES ,  Patrick Wilhelmus Antonius VRIJALDENHOVEN

IPC: A61K9/50 ,  C08K3/36 ,  C08K9/00 ,  C09D7/12 ,  C08K9/12 ,  C08L53/00 ,  C08K9/02

CPC classification number: A61K9/5089 ,  A61K9/501 ,  C08K3/36 ,  C08K9/00 ,  C08K9/02 ,  C08K9/12 ,  C08K2201/011 ,  C08K2201/013 ,  C08L53/00 ,  C08L2207/53 ,  C09D7/70 ,  G02B1/111 ,  Y10T428/254 ,  Y10T428/2998

Abstract: Compositions suitable for forming an optical coating are provided, wherein the compositions include core-shell nanoparticles having (a) a core material which includes a polymer; and (b) a shell material which includes a metal oxide.