公开(公告)号：US20180080936A1

公开(公告)日：2018-03-22

申请号：US15828017

申请日：2017-11-30

Applicant: Dako Denmark A/S

Inventor： Katherine Marks SOJKA ,  Elizabeth Oliver SPAULDING

IPC: G01N33/574

CPC classification number: G01N33/57476 ,  G01N33/5743

Abstract: The present invention discloses methods, for differentiating between normal or reactive cells and malignant cells biological samples comprising: exposing the biological sample to an antibody to L523S protein and detecting the presence of the antibody bound to L523S protein within the malignant cells. In embodiments, such methods may further comprise: exposing the biological sample to an antibody to a second protein that is a marker of cell lineage and detecting the presence of the antibody to the second protein within cells corresponding to a particular cell lineage and/or may comprise: exposing the biological sample to an antibody to a third protein which is a marker of cells that are normal or reactive and detecting the presence of the antibody to the third protein within cells that are normal or reactive.

公开(公告)号：US20150072891A1

公开(公告)日：2015-03-12

申请号：US14492171

申请日：2014-09-22

Applicant: DAKO DENMARK A/S

Inventor： Katherine Marks SOJKA ,  Elizabeth Oliver SPAULDING

IPC: G01N33/574

CPC classification number: G01N33/57476 ,  G01N33/5743

Abstract: The present invention discloses methods for differentiating between normal or reactive cells and malignant cells in biological samples comprising: exposing the biological sample to an antibody to L523S protein and detecting the presence of the antibody bound to L523S protein within the malignant cells, in embodiments, such methods may further comprise: exposing the biological sample to an antibody to a second protein that is a marker of cell lineage and detecting the presence of the antibody to the second protein within cells corresponding to a particular ceil lineage and/or may comprise: exposing the biological sample to an antibody to a third protein which is a marker of cells that are normal or reactive and detecting the presence of the antibody to the third protein within cells that are normal or reactive.

Abstract translation: 本发明公开了用于区分生物样品中的正常或反应性细胞与恶性细胞的方法，包括：将生物样品暴露于L523S蛋白的抗体，并检测在恶性细胞内与L523S蛋白结合的抗体的存在， 方法可以进一步包括：将生物样品暴露于作为细胞谱系标志物的第二蛋白质的抗体，并检测在对应于特定细胞谱系的细胞内第二种蛋白质的抗体的存在和/或可以包括： 生物样品与第三种蛋白质的抗体，其是正常或反应性细胞的标志物，并检测在正常或反应性细胞内第三种蛋白质的存在。