公开(公告)号：US20190314471A1

公开(公告)日：2019-10-17

申请号：US16455224

申请日：2019-06-27

Applicant: DAKO DENMARK A/S

Inventor： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

IPC: A61K39/00 ,  C07K14/74 ,  A61K39/12 ,  A61K39/21 ,  A61K47/61 ,  A61K47/64

Abstract: The present invention relates to methods for construction of pharmamers i.e. vaccine components characterized by their multimerization domain and the attached biologically active molecules, and their use in preparation of vaccines that contains the pharmamers alone or in combination with other molecules. The individual molecules of the construct can be bound to each other or the multimerization domain(s) by covalent or non-covalent bonds, directly or via linkers. The invention further relates to the use of such preparations in vaccine settings aimed to function as preventive/prophylactic or therapeutic vaccines in humans and animals.

公开(公告)号：US20200347114A1

公开(公告)日：2020-11-05

申请号：US16440627

申请日：2019-06-13

Applicant: DAKO DENMARK A/S

Inventor： Jørgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

IPC: C07K14/74 ,  G01N33/574 ,  G01N33/569 ,  A61K49/18 ,  A61K47/64 ,  A61K47/61

Abstract: Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.

公开(公告)号：US20190085048A1

公开(公告)日：2019-03-21

申请号：US16015955

申请日：2018-06-22

Applicant: Dako Denmark A/S

Inventor： Liselotte Brix ,  Henrik Pedersen ,  Tina Jakobsen ,  Jørgen Schøller ,  Jesper Lohse ,  Katja Brunstedt ,  Kivin Jacobsen

IPC: C07K14/74 ,  A61K47/66 ,  A61K47/64 ,  B82Y5/00

Abstract: The present invention describes novel methods to generate MHC multimers and methods to improve existing and new MHC multimers. The invention also describes improved methods for the use of MHC multimers in analysis of T-cells in samples including diagnostic and prognostic methods. Furthermore, the use of MHC multimers in therapy are described, e.g. anti-tumour and anti-virus therapy, including isolation of antigen specific T-cells capable of inactivation or elimination of undesirable targeT-cells or isolation of specific T-cells capable of regulation of other immune cells.