公开(公告)号：US06532061B2

公开(公告)日：2003-03-11

申请号：US09939292

申请日：2001-08-24

Applicant: William E. Ortyn ,  David A. Basiji ,  Richard A. Bauer ,  Keith L. Frost ,  David J. Perry ,  James K. Riley

Inventor： William E. Ortyn ,  David A. Basiji ,  Richard A. Bauer ,  Keith L. Frost ,  David J. Perry ,  James K. Riley

IPC: G01P336

CPC classification number: G02B27/0012 ,  G01N15/1012 ,  G01N15/1459 ,  G01N15/147 ,  G01N2015/1018 ,  G01N2015/1025 ,  G01N2015/1075 ,  G01N2015/144 ,  G01N2015/1443 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2015/1497 ,  G06T7/20

Abstract: Frequency domain velocity measurements and time domain velocity measurements are made using light from cells or other objects. An optical grating is used to modulate the light from an object so that it has a frequency proportional to the velocity of the object. Depending upon the embodiment, the pitch of the optical grating is uniform or varying. The modulated light is detected and various signal processing techniques, such as a Fast Fourier Transform function, are used to indicate the velocity of the object. Preferably, the velocity measured is applied in determining a timing signal employed for synchronization of an image of the object and an detector signal in an optical analysis system that uses a time delay integration detector to determine characteristics of the object in response to light from the object.

公开(公告)号：US5293721A

公开(公告)日：1994-03-15

申请号：US681573

申请日：1991-04-05

Applicant: James T. Richard ,  George J. Costigan ,  David J. Perry ,  Kevin T. Eldridge

Inventor： James T. Richard ,  George J. Costigan ,  David J. Perry ,  Kevin T. Eldridge

IPC: A01K39/01

CPC classification number: A01K39/0113

Abstract: A horizontal cable animal barrier for mounting on a cable to deter animal passage including a plurality of roller elements each having a central hole for rotatably mounting on a cable and a spacer element between each pair of roller elements and also having a central hole for rotatably mounting on the cable, in which the spacer elements are of a different size than the roller elements on either side to present an uneven, rotating barrier to animals on the cable to prevent the animals from passing.

Abstract translation: 一种用于安装在电缆上以阻止动物通道的水平电缆动物屏障，其包括多个滚子元件，每个滚子元件具有用于可旋转地安装在电缆上的中心孔和每对滚子元件之间的间隔元件，并且还具有用于可旋转地安装的中心孔 在电缆上，间隔元件的尺寸不同于任一侧上的滚子元件，以对电缆上的动物呈现不均匀的旋转屏障，以防止动物通过。

公开(公告)号：US06934408B2

公开(公告)日：2005-08-23

申请号：US09976237

申请日：2001-10-12

Applicant: Keith L. Frost ,  David A. Basiji ,  Richard A. Bauer ,  Rosalynde J. Finch ,  William E. Ortyn ,  David J. Perry

Inventor： Keith L. Frost ,  David A. Basiji ,  Richard A. Bauer ,  Rosalynde J. Finch ,  William E. Ortyn ,  David J. Perry

IPC: C12Q1/68 ,  C40B20/04 ,  C40B30/04 ,  C40B40/08 ,  C40B60/10 ,  G01N15/14 ,  G02B7/28 ,  G02B27/00 ,  G02B27/14 ,  G06K9/00

CPC classification number: G02B27/148 ,  C12Q1/6816 ,  C40B20/04 ,  C40B30/04 ,  C40B40/08 ,  C40B60/10 ,  G01N15/147 ,  G01N15/1475 ,  G01N2015/1447 ,  G01N2015/1472 ,  G01N2015/1479 ,  G01N2015/1497 ,  G02B7/28 ,  G02B27/0012 ,  G02B27/1013 ,  G02B27/126 ,  G02B27/144 ,  G02B27/145 ,  C12Q2563/179 ,  C12Q2563/155 ,  C12Q2563/107

Abstract: Combinatorially-synthesized deoxyribonucleic acid (DNA) oligonucleotides attached to encoded beads that are hybridized to amplified and labeled genomic DNA or ribonucleic acid (RNA) are analyzed using a flow imaging system. Oligonucleotides and corresponding reporters are bound to the surfaces of a plurality of small beads such that different beads bear different oligo sequences. Each bead bears a unique optical signature comprising a predefined number of unique reporters, where each reporter comprises a predefined combination of different fluorochromes. The composite spectral signature in turn identifies the unique nucleotide sequence of its attached oligo chains. This optical signature is rapidly decoded using an imaging system to discriminate the different reporters attached to each bead in a flow in regard to color and spatial position on the bead.

Abstract translation: 使用流动成像系统分析与编码的珠偶联的与扩增和标记的基因组DNA或核糖核酸（RNA）杂交的组合合成的脱氧核糖核酸（DNA）寡核苷酸。 寡核苷酸和相应的报道结合到多个小珠的表面，使得不同的珠具有不同的寡核苷酸序列。 每个珠具有唯一的光学特征，其包含预定数量的唯一记录器，其中每个报告者包含不同荧光染料的预定组合。 复合光谱特征依次识别其连接的寡链的唯一核苷酸序列。 使用成像系统快速解码该光学特征，以便鉴别珠子上颜色和空间位置的流动中附着于每个珠粒的不同报告者。

公开(公告)号：US06875973B2

公开(公告)日：2005-04-05

申请号：US10822170

申请日：2004-04-09

Applicant: William E. Ortyn ,  Michael J. Seo ,  David A. Basiji ,  Keith L. Frost ,  David J. Perry

Inventor： William E. Ortyn ,  Michael J. Seo ,  David A. Basiji ,  Keith L. Frost ,  David J. Perry

IPC: G01N15/10 ,  G01N15/14 ,  G02B27/00 ,  G06T7/20 ,  G02B27/40

CPC classification number: G06T7/20 ,  G01N15/1459 ,  G01N15/1463 ,  G01N2015/1018 ,  G01N2015/1443 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2015/1497 ,  G02B27/0012 ,  G06K9/00134

Abstract: A pair of optical gratings are used to modulate light from an object, and the modulated light from either optical is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.

Abstract translation: 一对光栅被用于调制来自物体的光，并且来自任一光学的调制光用于确定物体的速度。 每个光栅从参考焦点偏移相同的距离，一个光栅在正方向偏移，另一个光栅在负方向上偏移。 可以处理响应于调制光产生的信号以确定主收集透镜应该移动的方向，以便改善成像系统对物体的焦点。 透镜在如此确定的方向上逐渐移动，并重复该过程，直到达到最佳聚焦。 在优选实施例中，对信号进行加权，使得最靠近最佳聚焦位置布置的光栅最有助于速度检测。

公开(公告)号：US08991661B2

公开(公告)日：2015-03-31

申请号：US13084534

申请日：2011-04-11

Applicant: Anthony J. Arnone ,  Michael J. Helm ,  Jason L. Kerkeslager ,  David S. Payne ,  David J. Perry ,  Thomas H. Powers

Inventor： Anthony J. Arnone ,  Michael J. Helm ,  Jason L. Kerkeslager ,  David S. Payne ,  David J. Perry ,  Thomas H. Powers

IPC: G01F11/20 ,  B65G47/14

CPC classification number: B65G47/1485 ,  B65B25/062 ,  B65B25/067 ,  B65B35/06

Abstract: A material handling apparatus for conveying an article having a ferromagnetic component includes a hopper, a discharge, and a magnet. The hopper has an inlet and outlet and defines a hopper volume for receiving a plurality of the articles to be conveyed. The discharge is spaced from and downstream of the hopper. The magnet is movable between an attracting position proximate the hopper and a discharge position proximate the discharge.

Abstract translation: 用于输送具有铁磁性部件的物品的材料处理装置包括料斗，排出部和磁铁。 料斗具有入口和出口，并且限定用于接收多个待输送物品的料斗体积。 排放物与料斗间隔开和下游。 磁体可以在靠近料斗的吸引位置和靠近排出口的排出位置之间移动。

公开(公告)号：US20120257951A1

公开(公告)日：2012-10-11

申请号：US13084534

申请日：2011-04-11

Applicant: Anthony J. Arnone ,  Michael J. Helm ,  Jason L. Kerkeslager ,  David S. Payne ,  David J. Perry ,  Thomas H. Powers

Inventor： Anthony J. Arnone ,  Michael J. Helm ,  Jason L. Kerkeslager ,  David S. Payne ,  David J. Perry ,  Thomas H. Powers

IPC: B65G65/34

CPC classification number: B65G47/1485 ,  B65B25/062 ,  B65B25/067 ,  B65B35/06

Abstract: A material handling apparatus for conveying an article having a ferromagnetic component includes a hopper, a discharge, and a magnet. The hopper has an inlet and outlet and defines a hopper volume for receiving a plurality of the articles to be conveyed. The discharge is spaced from and downstream of the hopper. The magnet is movable between an attracting position proximate the hopper and a discharge position proximate the discharge.

Abstract translation: 用于输送具有铁磁性部件的物品的材料处理装置包括料斗，排出部和磁铁。 料斗具有入口和出口，并且限定用于接收多个待输送物品的料斗体积。 排放物与料斗间隔开和下游。 磁体可以在靠近料斗的吸引位置和靠近排出口的排出位置之间移动。

公开(公告)号：US20110203943A1

公开(公告)日：2011-08-25

申请号：US12711995

申请日：2010-02-24

Applicant: David J. Perry ,  John M. Sherry

Inventor： David J. Perry ,  John M. Sherry

IPC: B65D81/26 ,  B05D1/36 ,  B32B3/22

CPC classification number: C09D11/033 ,  C09D11/037 ,  C09D11/106 ,  Y10T428/24802

Abstract: The invention generally relates to an absorbent article comprising an absorbent having printed indicia thereon wherein the printing comprises colorant and resin, and a protective coating over the printing.

Abstract translation: 本发明一般涉及一种吸收制品，其包括其上具有印刷标记的吸收剂，其中印刷物包括着色剂和树脂，以及印刷上的保护涂层。

公开(公告)号：US07889263B2

公开(公告)日：2011-02-15

申请号：US12754504

申请日：2010-04-05

Applicant: William E. Ortyn ,  David A. Basiji ,  David J. Perry

Inventor： William E. Ortyn ,  David A. Basiji ,  David J. Perry

IPC: H04N5/225

CPC classification number: G02B27/1086 ,  B01J2219/00274 ,  C07K1/047 ,  C12Q1/6816 ,  G01N15/1434 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/031 ,  G01N21/05 ,  G01N2015/0294 ,  G01N2015/1443 ,  G01N2015/1452 ,  G01N2015/1472 ,  G01N2015/1479 ,  G01N2015/1488 ,  G01N2021/0346 ,  G01N2021/052 ,  G01N2021/058 ,  G02B7/28 ,  G02B21/00 ,  G02B27/0012 ,  G02B27/126 ,  G02B27/144 ,  G02B27/145 ,  H04N5/2254 ,  H04N5/23212 ,  C12Q2563/179 ,  C12Q2563/107

Abstract: A system and method for high numeric aperture imaging systems includes a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the transmitted portion and reflected portion are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved.

Abstract translation: 用于高数值孔径成像系统的系统和方法包括分离器，散焦系统和组合器。 分离器反射收集的光的一部分并透射另一部分收集的光。 散焦系统被配置为修改所收集的光的透射部分或反射部分的光焦度。 组合器相对于机械角度定向。 组合器将透射部分和反射部分的部分重新组合，使得透射部分和反射部分随后通过基于组合器的取向的机械角度的光学分离角度被分离。 使用各种其他实施方式来保持关于所涉及的成像系统的焦点。

公开(公告)号：US07087877B2

公开(公告)日：2006-08-08

申请号：US11045675

申请日：2005-01-28

Applicant: William E. Ortyn ,  Michael J. Seo ,  David A. Basiji ,  Keith L. Frost ,  David J. Perry

Inventor： William E. Ortyn ,  Michael J. Seo ,  David A. Basiji ,  Keith L. Frost ,  David J. Perry

IPC: G02B27/40

CPC classification number: G06T7/20 ,  G01N15/1459 ,  G01N15/1463 ,  G01N2015/1018 ,  G01N2015/1443 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2015/1497 ,  G02B27/0012 ,  G06K9/00134

Abstract: A pair of optical gratings are used to modulate light from an object, and the modulated light from either grating is used to determine the velocity of the object. Each optical grating is offset from a reference focal point by the same distance, one grating being offset in a positive direction, the other in a negative direction. Signals produced in response to the modulated light can be processed to determine a direction in which a primary collection lens should be moved in order to improve a focus of the imaging system on the object. The lens is moved incrementally in the direction so determined, and the process is repeated until an optimal focus is achieved. In a preferred embodiment, the signals are weighted, so that the optical grating disposed closest to the optimal focus position contributes the most to velocity detection.

Abstract translation: 一对光栅用于调制来自物体的光，并且来自任一光栅的调制光用于确定物体的速度。 每个光栅从参考焦点偏移相同的距离，一个光栅在正方向偏移，另一个光栅在负方向上偏移。 可以处理响应于调制光产生的信号以确定主收集透镜应该移动的方向，以便改善成像系统对物体的焦点。 透镜在如此确定的方向上逐渐移动，并重复该过程，直到达到最佳聚焦。 在优选实施例中，对信号进行加权，使得最靠近最佳聚焦位置布置的光栅最有助于速度检测。

公开(公告)号：US06453060B1

公开(公告)日：2002-09-17

申请号：US09343172

申请日：1999-06-29

Applicant: James K. Riley ,  Michael G. Meyer ,  David J. Perry ,  Andrew D. Silber

Inventor： James K. Riley ,  Michael G. Meyer ,  David J. Perry ,  Andrew D. Silber

IPC: G06K900

CPC classification number: G06K9/00127 ,  G01N15/1468 ,  G01N2015/1472

Abstract: A system for collecting images at multiple wavelengths for image analysis of biological specimens. The process separates contrasts for images of a biological specimen prepared with a chromogen. Light wavelengths matched with each chromogen optimize separation for each image. Computing attenuation coefficients and extinction coefficients for each chromogen provides for determination of the concentration of each chromogen. A chromogen separator allows for subtracting predetermined chromogens to generate new images and aid in identification of cell morphology. The system can perform the image analysis of the new images using image processing techniques such as segmentation, feature calculation and object classification. At each stage of image processing, data from each of the new images may influence the processing of the other images.

Abstract translation: 一种用于收集多个波长图像以进行生物样本图像分析的系统。 该过程分离了用色原体制备的生物样品的图像的对比度。 与每个色原相匹配的光波长优化每个图像的分离。 计算每个色原体的衰减系数和消光系数可以确定每个色原的浓度。 色原分离器允许减去预定的色原体以产生新图像并有助于细胞形态的鉴定。 该系统可以使用分割，特征计算和对象分类等图像处理技术对新图像进行图像分析。 在图像处理的每个阶段，来自每个新图像的数据可能影响其他图像的处理。