公开(公告)号：US20180264176A1

公开(公告)日：2018-09-20

申请号：US15758390

申请日：2016-09-08

Applicant: ETH Zurich

Inventor： Nicolas BROGUIERE ,  Marcy ZENOBI-WONG

IPC: A61L27/52 ,  C08J3/075 ,  C08J9/28 ,  C08L53/00 ,  C08L79/00 ,  C08L71/08 ,  C08L5/02

CPC classification number: A61L27/52 ,  A61L27/18 ,  A61L27/20 ,  A61L27/227 ,  A61L27/26 ,  A61L27/3804 ,  A61L27/56 ,  C08G65/3322 ,  C08J3/075 ,  C08J9/286 ,  C08L5/02 ,  C08L5/08 ,  C08L53/00 ,  C08L71/02 ,  C08L71/08 ,  C08L79/00 ,  C08L2201/54

Abstract: The inventions relates to a method for generating a macroporous hydrogel. In a first step, an aqueous solution of two solutes is produced. The first solute is a polymer that can be cross-linked and is a derivative of polyethylene glycol (PEG) or polyoxazoline (POx) and the second solute is a kosmotropic agent. In a second step, a cross-linking agent is added to the solution. This simultaneously initiates gelation of the polymer and phase-separation, thus creating a macroporous hydrogel. The invention further relates to a macroporous hydrogel, which can be obtained by the inventive method. This macroporous hydrogel is comprised of a cross-linked polymer, which is a derivative of polyethylene glycol (PEG) or polyoxazoline (POx). The hydrogel exhibits interconnected macropores with a size of 200 nm to 1000 μm, particularly 500 nm to 100 μm and is characterized by a pH of of 7.0 to 8.0, particularly approx. 7.4.