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    Method for treating viral infections
    1.
    发明授权
    Method for treating viral infections 失效
    治疗病毒感染的方法

    公开(公告)号：US06323012B1

    公开(公告)日：2001-11-27

    申请号：US09234935

    申请日：1999-01-21

    Applicant: Ehud Ben-Hur ,  Zvi Malik

    Inventor： Ehud Ben-Hur ,  Zvi Malik

    IPC: A01N102

    CPC classification number: A61K31/197 ,  A61K31/195 ,  A61K31/16 ,  A61K2300/00

    Abstract: The present invention provides a method for treating a viral infection in a subject. The method comprises administering to the subject an amount of 5-aminolevulinic acid to cause virus-infected cells to accumulate protoporphyrin in amounts such that upon application of a sufficient dose of red light, the virus-infected, protoporphyrin-accumulated cells will be destroyed; and applying a sufficient dose of red light to the virus-infected, protoporphyrin-accumulated cells to destroy the virus-infected, protoporphyrin-accumulated cells.

    Abstract translation: 本发明提供了治疗受试者的病毒感染的方法。 该方法包括给予受试者一定量的5-氨基乙酰丙酸以使病毒感染的细胞积累原卟啉的量，使得在施用足够剂量的红光时，病毒感染的原卟啉积累的细胞将被破坏; 并向病毒感染的原卟啉积累的细胞施加足够剂量的红光以破坏病毒感染的原卟啉积累的细胞。

    Methods for treating viral infections
    2.
    发明授权
    Methods for treating viral infections 失效

    公开(公告)号：US6103706A

    公开(公告)日：2000-08-15

    申请号：US841042

    申请日：1997-04-29

    Applicant: Ehud Ben-Hur

    Inventor： Ehud Ben-Hur

    IPC: A61K41/00 ,  C12N13/00 ,  A61K31/695 ,  A61K31/395

    CPC classification number: C12N13/00 ,  A61K41/0071

    Abstract: The present invention provides a method for treating a viral infection in a subject in need of such treatment comprising administering to the subject a photosensitizer formulated in a liposome carrier, and exposing the subject to light at a wavelength 20-40 nm greater than the maximum absorption of the photosensitizer at a sufficient dose and duration to treat the viral infection in the subject. The present invention also provides a method for treating a viral infection in a subject in need of such treatment comprising administering to the subject (i) a photosensitizer formulated in a liposome carrier and (ii) at least one quencher, and exposing the subject to light at a sufficient wavelength, dose and duration to treat the viral infection in the subject.

    Process for the sterilization of biological compositions and the product produced thereby
    3.
    发明授权
    Process for the sterilization of biological compositions and the product produced thereby 失效
    用于生物组合物的灭菌和由此产生的产品的方法

    公开(公告)号：US06413714B1

    公开(公告)日：2002-07-02

    申请号：US09580250

    申请日：2000-05-26

    Applicant: Henrietta Margolis-Nunno ,  Ehud Ben-Hur ,  Bernard Horowitz

    Inventor： Henrietta Margolis-Nunno ,  Ehud Ben-Hur ,  Bernard Horowitz

    IPC: A01N102

    CPC classification number: A61K41/0019 ,  A61K41/0066 ,  A61L2/0011 ,  A61L2/10 ,  C12N7/00 ,  C12N7/06 ,  C12N2760/20263

    Abstract: The present invention concerns a process for inactivating extracellular and intracellular virus in a biological composition without incurring substantial disruption or inactivation thereof, said process comprising subjecting said composition to a virucidally effective amount of UVA1 irradiation substantially in the absence of UVA2 irradiation for a period of time sufficient to thereby inactivate said virus while retaining functionality of said composition. The biological composition is advantageously a product that contains red blood cells or platelets. The process is advantageously carried out in the presence of an irradiation sensitizer compound and/or a quencher. The present invention also concerns the product substantially identical to that produced by the inventive process.

    Abstract translation: 本发明涉及使生物组合物中的细胞外和细胞内病毒灭活而不引起实质性破坏或失活的方法，所述方法包括使所述组合物基本上在不存在UVA2照射的情况下对所述组合物进行病毒有效量的UVA1照射一段时间 足以使所述病毒灭活同时保留所述组合物的功能。 生物组合物有利地是含有红细胞或血小板的产品。 该方法有利地在辐照敏化剂化合物和/或猝灭剂的存在下进行。 本发明还涉及与本发明方法产生的产品基本相同的产品。

    Methods for treating viral infections
    4.
    发明授权
    Methods for treating viral infections 失效
    治疗病毒感染的方法

    公开(公告)号：US06348453B1

    公开(公告)日：2002-02-19

    申请号：US09543607

    申请日：2000-04-05

    Applicant: Ehud Ben-Hur

    Inventor： Ehud Ben-Hur

    IPC: A61K31555

    CPC classification number: C12N13/00 ,  A61K41/0071

    Abstract: The present invention provides a method for treating a viral infection in a subject in need of such treatment comprising administering to the subject a photosensitizer formulated in a liposome carrier, and exposing the subject to light at a wavelength 20-40 nm greater than the maximum absorption of the photosensitizer at a sufficient dose and duration to treat the viral infection in the subject. The present invention also provides a method for treating a viral infection in a subject in need of such treatment comprising administering to the subject (i) a photosensitizer formulated in a liposome carrier and (ii) at least one quencher, and exposing the subject to light at a sufficient wavelength, dose and duration to treat the viral infection in the subject.

    Abstract translation: 本发明提供了一种治疗需要这种治疗的受试者的病毒感染的方法，包括向受试者施用配制在脂质体载体中的光敏剂，并将受试者暴露于大于最大吸收的20-40nm波长的光 的光敏剂以足够的剂量和持续时间来治疗受试者的病毒感染。 本发明还提供了一种治疗需要这种治疗的受试者的病毒感染的方法，包括对受试者施用（i）配制在脂质体载体中的光敏剂和（ii）至少一种猝灭剂，并使受试者暴露于光 以足够的波长，剂量和持续时间来治疗受试者的病毒感染。

    Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells
    5.
    发明授权
    Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells 失效
    以更高的光通量对酞菁红和红光进行光动力治疗红细胞是保护红细胞的

    公开(公告)号：US5637451A

    公开(公告)日：1997-06-10

    申请号：US413054

    申请日：1995-03-29

    Applicant: Ehud Ben-Hur ,  Bernard Horowitz

    Inventor： Ehud Ben-Hur ,  Bernard Horowitz

    IPC: A61K41/00 ,  A61L2/00 ,  A01N1/02 ,  A01N63/00 ,  C12N7/06

    CPC classification number: A61L2/0011 ,  A61K41/0071

    Abstract: An improved process for inactivating an extracellular lipid enveloped virus or an intracellular lipid enveloped virus which may be present in an extracorporeal composition containing red blood cells by subjecting the composition to a virucidally effective amount of a phthalocyanine compound and red light of a fluence rate of at least above about 5 mW/cm.sup.2. Quite contrary to what would have been expected, it has been found that higher light fluence rates are, in fact, more protective of red blood cells than are lower light fluence rates.

    Abstract translation: 一种用于灭活细胞外脂质包膜病毒或细胞内脂质包膜病毒的改进方法，所述方法可以通过使组合物经受病毒有效量的酞菁化合物和通量密度为红细胞的红光来存在于含有红细胞的体外组合物中 至少高于约5mW / cm 2。 与预期的相反，已经发现，更高的光通量实际上比较低的光通量率更加保护红细胞。

    Viral inactivation treatment of red blood cells using phthalocyanines and red light
    8.
    发明授权
    Viral inactivation treatment of red blood cells using phthalocyanines and red light 有权
    使用酞菁和红光对红细胞进行病毒灭活处理

    公开(公告)号：US6090599A

    公开(公告)日：2000-07-18

    申请号：US68230

    申请日：1998-09-01

    Applicant: Ehud Ben-Hur

    Inventor： Ehud Ben-Hur

    IPC: A01N1/02 ,  A61K41/00 ,  A61L2/00 ,  C12N13/00 ,  C12N7/04 ,  A61M37/00

    CPC classification number: A61K41/0071 ,  A61L2/0011 ,  A61L2/0088 ,  A61M2205/052

    Abstract: Disclosed are two processes. The first process involves treating a red blood cell-containing composition to inactivate an extracellular or intracellular virus which may be present in said red blood cell-containing composition by subjecting said red blood cell-containing composition to a virucidally effective amount of a phthalocyanine and red light, wherein the improvement involves (i) determining the action spectrum of said phthalocyanine for causing inactivation of said virus; (ii) determining the action spectrum of said phthalocyanine for causing red blood cell damage; (iii) comparing (i) and (ii), and, if (i) and (ii) are not identical then determining the wavelength at which the largest favorable difference exists between (i) and (ii); (iv) providing a red light source emitting red light only in 10 nm in either direction of the wavelength determined in (iii); and then (v) subjecting said red blood cell-containing composition to said virucidally effective amount of said phthalocyanine and said provided red light source. In a preferred embodiment, the phthalocyanine is Pc 4, which has the formula: HOSiPcOSi(CH.sub.3).sub.2 (CH.sub.2).sub.3 N(CH.sub.3).sub.2. The second process involves transfusing red blood cells to a patient in need thereof by withdrawing red blood cells from a donor, subjecting the red blood cells to the first process and transfusing the red blood cells to said patient.

    Abstract translation: PCT No.PCT / US96 / 17528 Sec。 371日期：1998年9月1日 102（e）1998年9月1日PCT PCT 1996年11月4日PCT公布。 公开号WO97 / 16966 PCT 日期1997年5月15日被公开是两个过程。 第一种方法包括处理含有红细胞的组合物以使所述含红细胞的组合物中可能存在的细胞外或细胞内病毒灭活，使所述含红细胞的组合物具有杀病毒有效量的酞菁和红色 光，其中改进包括（i）确定所述酞菁的作用谱，以使所述病毒灭活; （ii）确定所述酞菁的引起红细胞损伤的作用光谱; （iii）比较（i）和（ii），并且如果（i）和（ii）不相同，则确定在（i）和（ii）之间存在最大有利差异的波长; （iv）提供在（iii）中确定的波长的任一方向上仅在10nm发射红光的红色光源; 然后（v）使所述含红细胞的组合物对所述杀病毒有效量的所述酞菁和所述提供的红色光源进行处理。 在优选的实施方案中，酞菁是Pc 4，其具有下式：HOSiPcOSi（CH3）2（CH2）3N（CH3）2）。 第二个过程涉及通过从供体抽出红细胞，使红细胞进行第一过程并将红细胞输送给所述患者，将红细胞输送给有需要的患者。

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