公开(公告)号：US20230181473A1

公开(公告)日：2023-06-15

申请号：US17916618

申请日：2021-04-16

Applicant: Elektrofi, Inc.

Inventor： Jason G. Auer ,  Paul Brown ,  Tyler L. Carter ,  Chase Spenser Coffman ,  Paul F. Herbert ,  James W. Ivey ,  Moin Khwaja ,  Lisa Liu ,  Sadiqua Shadbar ,  Shankul Vartak

IPC: A61K9/16 ,  B01J13/04 ,  A61K41/17 ,  A61K38/38 ,  A61K39/395

CPC classification number: A61K9/1694 ,  B01J13/04 ,  A61K41/17 ,  A61K38/385 ,  A61K39/3955 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652

Abstract: The present disclosure relates to methods that enable the continuous formation of droplets and dehydration of droplets to provide pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled continuous droplet formation and dehydration that produce circular particles having low internal void spaces comprising bioactive therapeutic biologies.

公开(公告)号：US20240270864A1

公开(公告)日：2024-08-15

申请号：US18633795

申请日：2024-04-12

Applicant: Elektrofi, Inc.

Inventor： Paul Brown ,  Daniel Benjamin Dadon ,  James W. Ivey ,  Moin Khwaja ,  Lisa Liu ,  Jeremy Schieferstein ,  Sadiqua Shadbar

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/00 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/44 ,  C07K16/06 ,  C07K16/32

CPC classification number: C07K16/2887 ,  A61K9/0019 ,  A61K47/14 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/44 ,  C07K16/06 ,  C07K16/32 ,  A61K2039/505 ,  A61K2039/54

Abstract: The present disclosure provides high concentration injectable particle suspensions of therapeutic biologics that permit administration without the need for resuspension. In particular, the compositions disclosed herein are highly concentrated low volume injectable particle suspensions that do not require manual premixing or resuspension prior to administration.