公开(公告)号：US20130138354A1

公开(公告)日：2013-05-30

申请号：US13674719

申请日：2012-11-12

Applicant: Arizona Board of Regents for and behalf of Arizona ,  FORENSIC SCIENCE SERVICE LIMITED

Inventor： Frederic ZENHAUSERN ,  Ralf LENIGK ,  Andrew HOPWOOD ,  Pieris KOUMI

IPC: G06F17/00

CPC classification number: G01N1/28 ,  B01L3/502753 ,  B01L2300/024 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q2600/166 ,  G01D21/00 ,  G01N27/44791 ,  G01N33/487 ,  G01N33/6803 ,  G01N2030/045 ,  G06F17/00

Abstract: A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position.

公开(公告)号：US20150047413A1

公开(公告)日：2015-02-19

申请号：US14336479

申请日：2014-07-21

Applicant: Arizona Board of Regents for and on behalf of Arizona State University ,  Forensic Science Service Limited

Inventor： Frederic ZENHAUSERN ,  Ralf LENIGK ,  Andrew HOPWOOD ,  Pieris KOUMI

IPC: G01N1/28 ,  G01N33/68 ,  G01N33/487 ,  C12Q1/68 ,  G01D21/00

CPC classification number: G01N1/28 ,  B01L3/502753 ,  B01L2300/024 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q2600/166 ,  G01D21/00 ,  G01N27/44791 ,  G01N33/487 ,  G01N33/6803 ,  G01N2030/045 ,  G06F17/00

Abstract: A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position.

Abstract translation: 提供了一种验证在核酸分析方法中使用的由多个尺寸标准元素形成的尺寸标准的性能的方法。 通过将尺寸标准引入分析阶段并根据尺寸标准执行基于尺寸的分离来实现验证。 基于尺寸的分离定义了每个尺寸标准元素的实验位置。 比较尺寸标准元件的实验位置是否对应于预期位置。 该比较允许决定是否使用尺寸标准，这取决于尺寸标准件的实验位置是否与预期位置相对应。

公开(公告)号：US20140178938A1

公开(公告)日：2014-06-26

申请号：US13936685

申请日：2013-07-08

Applicant: Forensic Science Service Limited ,  The Arizona Board of Regents acting for and on behalf of Arizona State University

Inventor： Frederic ZENHAUSERN ,  Alan NORDQUIST ,  Ralf LENIGK ,  Cedric HURTH ,  Jianing YANG ,  Xiaojia CHEN ,  Matthew ESTES ,  John LEE-EDGHILL ,  Nina MORAN ,  Andrew HOPWOOD ,  Pieris KOUMI ,  Zhi CAI

IPC: C12Q1/68

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/502738 ,  B01L7/52 ,  B01L7/525 ,  C12Q1/6806 ,  C25B9/00 ,  G01N1/10 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N27/44791 ,  G01N2021/6484 ,  G01N2201/062 ,  G01N2201/0846 ,  Y10T436/143333

Abstract: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.

Abstract translation: 提供了一种方法和设备结构，其使得能够相对于在其中提供诸如PCR的一系列过程的设备来收集和分离归档样本。 提供了一种室结构和使用方法，其中通过控制通过各种通道的相对阻力获得受控和精确的体积。

公开(公告)号：US20150111215A1

公开(公告)日：2015-04-23

申请号：US14283709

申请日：2014-05-21

Applicant: FORENSIC SCIENCE SERVICE LIMITED

Inventor： Gary ROSS ,  Sebastian WETHERALL ,  Owen EVANS ,  Andrew HOPWOOD ,  Nina MORAN

IPC: G01N1/44 ,  C12N15/10 ,  B01L3/00 ,  C12Q1/68 ,  B01L7/00

CPC classification number: G01N1/44 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0216 ,  B01L3/502715 ,  B01L3/5029 ,  B01L3/50825 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/041 ,  B01L2300/044 ,  B01L2300/049 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2300/1805 ,  B01L2400/0475 ,  B01L2400/0478 ,  B01L2400/0644 ,  B01L2400/0683 ,  C12N15/1003 ,  C12Q1/6806 ,  G01N1/28

Abstract: The invention provides containers and methods of use for the storage, transportation and preparation of samples, such as DNA samples for analysis. The container is pre-provided with the reagents in sealed chambers. The sample can be introduced and the container manipulated to release the reagents, provide the necessary conditions and give a fully prepared sample. The container can then be engaged with an analysis device to identify characteristics of the sample or perform other operations thereon.

Abstract translation: 本发明提供用于储存，运输和制备样品的容器和方法，例如用于分析的DNA样品。 容器在密封室中预先装有试剂。 可以引入样品并操作容器以释放试剂，提供必要的条件并给出完全准备的样品。 然后可以将容器与分析装置接合以识别样品的特征或对其进行其它操作。

公开(公告)号：US20130316335A1

公开(公告)日：2013-11-28

申请号：US13892844

申请日：2013-05-13

Applicant: GRID XITEK LIMITED ,  FORENSIC SCIENCE SERVICE LIMITED

Inventor： Gary ROSS ,  Sebastian WETHERALL ,  Owen EVANS ,  Andrew HOPWOOD ,  Nina MORAN

IPC: G01N1/28

CPC classification number: G01N1/44 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0216 ,  B01L3/502715 ,  B01L3/5029 ,  B01L3/50825 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/041 ,  B01L2300/044 ,  B01L2300/049 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2300/1805 ,  B01L2400/0475 ,  B01L2400/0478 ,  B01L2400/0644 ,  B01L2400/0683 ,  C12N15/1003 ,  C12Q1/6806 ,  G01N1/28

Abstract: The invention provides containers and methods of use for the storage, transportation and preparation of samples, such as DNA samples for analysis. The container is pre-provided with the reagents in sealed chambers. The sample can be introduced and the container manipulated to release the reagents, provide the necessary conditions and give a fully prepared sample. The container can then be engaged with an analysis device to identify characteristics of the sample or perform other operations thereon.