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    COMPOUND AND LABELED BIOLOGICAL SUBSTANCE USING THE SAME
    1.
    发明公开
    COMPOUND AND LABELED BIOLOGICAL SUBSTANCE USING THE SAME 审中-公开

    公开(公告)号：US20230219932A1

    公开(公告)日：2023-07-13

    申请号：US18048426

    申请日：2022-10-20

    Applicant: FUJIFILM Corporation

    Inventor： Yoshinori KANAZAWA ,  Ryo FUJIWARA ,  Kenji SHIROKANE ,  Kousuke WATANABE ,  Yuki ARAI ,  Kazuoki KOMIYAMA ,  Hiroaki TANAKA

    IPC: C07D403/08 ,  C07D471/04

    CPC classification number: C07D403/08 ,  C07D471/04

    Abstract: There are provided a compound of Formula (1) and a labeled biological substance having the compound.





    Z1 and Z2 represent a specific 6-membered ring. However, at least one of Z1 or Z2 is a benzene ring having a specific substituent at an ortho position with respect to a nitrogen atom to which L1 or L2 is bonded, or a specific nitrogen-containing 6-membered ring in which a ring-constituting atom located at the ortho position is a nitrogen atom.
    R1 to R4, R11 to R13, L1, L2, and R21 represents specific groups, and n, α1, α2, and m represent specific numbers.
    The compound has at least one structure represented by —(CH2—CH2—O)m-R21 on a heterocyclic ring and has at least one substituent capable of being bonded to a carboxy group or a biological substance at a specific position, and in a case where at least one of Z1 or Z2 is the specific nitrogen-containing 6-membered ring, the specific substituents may be bonded to each other to form a ring.

    FLUORESCENT COMPOUND AND FLUORESCENT LABELED BIOLOGICAL SUBSTANCE USING THE SAME
    2.
    发明申请
    FLUORESCENT COMPOUND AND FLUORESCENT LABELED BIOLOGICAL SUBSTANCE USING THE SAME 有权

    公开(公告)号：US20210088526A1

    公开(公告)日：2021-03-25

    申请号：US17105638

    申请日：2020-11-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiyoku NAKATA ,  Kousuke WATANABE ,  Akihiro ASAKURA ,  Keiko MAKITA ,  Yoshinori KANAZAWA ,  Kazuhei KANEKO

    IPC: G01N33/58 ,  C09K11/06 ,  C09B23/06 ,  G01N21/64

    Abstract: Provided are any one of the following fluorescent compounds and a fluorescent labeled biological substance having this fluorescent compound. X represents CR5 or N, and R1 to R7, Q1, Q2, L1, and L2 each represent a specific group.
    a ring β1 and a ring β2 are a 5- to 8-membered ring,
    At least one of R1 to R7, L1, L2, Q1, or Q2 has a specific hydrophilic group.
    However, in a case where the ring β1 and the ring β2 are a 6-membered ring, and L1 and L2 are an arylene group, R5 is not an aryl group substituted with a linear alkyl group having 18 or more carbon atoms. In addition to the regulation of the ring β1, the ring β2, L1, and L2, in a case where R5 has a substituent having a dipyrromethene boron complex structure, the dipyrromethene boron complex structure has a structure in which a dipyrromethene skeleton is coordinately bonded to a boron atom in the tridentate or tetradentate coordination.

    PROGESTERONE MEASUREMENT KIT, PROGESTERONE MEASUREMENT METHOD, AND PROGESTERONE MEASUREMENT REAGENT
    5.
    发明申请
    PROGESTERONE MEASUREMENT KIT, PROGESTERONE MEASUREMENT METHOD, AND PROGESTERONE MEASUREMENT REAGENT 审中-公开

    公开(公告)号：US20200378962A1

    公开(公告)日：2020-12-03

    申请号：US16999138

    申请日：2020-08-21

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki CHIKU ,  Takeru SHIGEMURA ,  Kousuke WATANABE ,  Yoshinori KANAZAWA ,  Kouitsu SASAKI ,  Kazuhei KANEKO

    IPC: G01N33/543 ,  G01N33/547 ,  G01N21/64

    Abstract: An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of progesterone in a wide concentration range from a low concentration to a high concentration, in the measurement of progesterone in a biological sample. The present invention provides a progesterone measuring kit including a first particle having a label and modified with a first binding substance, a second particle having no label and modified with a second binding substance, a flow channel, and a substrate, in which the first particle contains a compound represented by Formula (1) and a particle, and an average particle diameter of the first particles is 50 to 250 nm, an average particle diameter of the second particles is 70 to 500 nm, and the average particle diameter of the second particles is larger than the average particle diameter of the first particles. Each symbol in the formula has the meaning described in the present specification.

    PHOTOELECTRIC CONVERSION ELEMENT, DYE-SENSITIZED SOLAR CELL, METAL COMPLEX DYE, AND DYE SOLUTION
    7.
    发明申请
    PHOTOELECTRIC CONVERSION ELEMENT, DYE-SENSITIZED SOLAR CELL, METAL COMPLEX DYE, AND DYE SOLUTION 审中-公开

    公开(公告)号：US20170092434A1

    公开(公告)日：2017-03-30

    申请号：US15372471

    申请日：2016-12-08

    Applicant: FUJIFILM Corporation

    Inventor： Kazuhiro TSUNA ,  Kousuke WATANABE ,  Hiroki SUGIURA ,  Tomoaki YOSHIOKA ,  Toshihiro ISE

    IPC: H01G9/20 ,  C07F15/00 ,  H01L51/00 ,  C09B57/10

    CPC classification number: H01G9/2059 ,  C07F15/0053 ,  C09B23/105 ,  C09B57/10 ,  H01G9/2018 ,  H01G9/2022 ,  H01G9/2027 ,  H01L51/0086 ,  Y02E10/542

    Abstract: A photoelectric conversion element having an electrically conductive support, a photoconductor layer including an electrolyte, a charge transfer layer including an electrolyte, and a counter electrode, in which the photoconductor layer has semiconductor fine particles carrying a metal complex dye represented by the following Formula (1), and a dye-sensitized solar cell; and a metal complex dye and a dye solution, each of which is used in the photoelectric conversion element and the dye-sensitized solar cell, ML1L2(X)n1.CImY  Formula (1) in the formula, M represents a metal ion, L1 represents a tridentate ligand having a group LV represented by the following Formula (LV-1) or (LV-2); L2 represents a bidentate or tridentate ligand including at least one of aromatic ring groups having a specific sp2 carbon atom to which a substituent is bonded; X represents a monodentate ligand; n1 represents 0 or 1; CI represents a required counterion; and mY represents an integer of 0 to 3, —RV1═RV2—RV31  Formula (LV-1) —C≡C—RV32  Formula (LV-2) in the formulae, RV1 and RV2 each independently represent a nitrogen atom or CRV4, RV4 represents a hydrogen atom or a substituent, RV31 represents a fused polycyclic aromatic ring group or a fused polycyclic heterocyclic group, and RV32 represents a fused polycyclic aromatic ring group or a heteroaryl group.

    KIT, METHOD AND REAGENT FOR MEASURING MEASUREMENT TARGET SUBSTANCE
    9.
    发明申请
    KIT, METHOD AND REAGENT FOR MEASURING MEASUREMENT TARGET SUBSTANCE 审中-公开

    公开(公告)号：US20200096445A1

    公开(公告)日：2020-03-26

    申请号：US16585406

    申请日：2019-09-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki CHIKU ,  Tomoaki YOSHIOKA ,  Kousuke WATANABE ,  Kazuhiro HAMADA ,  Kouitsu SASAKI

    IPC: G01N21/64 ,  G01N33/543 ,  C07F5/02

    Abstract: An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of a measurement target substance in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance, the kit including: a first particle having a label and modified with a first binding substance; a second particle having no label and modified with a second binding substance; a flow channel for flowing the first particle and the second particle; and a substrate having a third binding substance capable of specifically binding to the measurement target substance or a substance capable of binding to the first binding substance, in which the first particle having a label is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.

    KIT, METHOD, AND REAGENT FOR MEASURING MEASUREMENT TARGET SUBSTANCE
    10.
    发明申请
    KIT, METHOD, AND REAGENT FOR MEASURING MEASUREMENT TARGET SUBSTANCE 审中-公开

    公开(公告)号：US20200025771A1

    公开(公告)日：2020-01-23

    申请号：US16585758

    申请日：2019-09-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki CHIKU ,  Kousuke WATANABE ,  Kazuhei KANEKO ,  Kazuhiro HAMADA ,  Kouitsu SASAKI ,  Tomoaki YOSHIOKA ,  Naoyuki HANAKI

    IPC: G01N33/58 ,  C07D209/56

    Abstract: An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of a measurement target substance in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance, the kit including: a first particle having a label and modified with a first binding substance capable of specifically binding to a measurement target substance; a second particle having no label and modified with a second binding substance incapable of specifically binding to the measurement target substance; a flow channel for flowing the first particle and the second particle; and a substrate having a third binding substance capable of specifically binding to the measurement target substance or a substance capable of binding to the first binding substance, in which the first particle having a label is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.

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