公开(公告)号：US10471180B2

公开(公告)日：2019-11-12

申请号：US15374604

申请日：2016-12-09

Applicant: FUJIFILM Corporation

Inventor： Reiko Iwazawa ,  Kentaro Nakamura

IPC: A61L27/38 ,  A61L27/22 ,  A61K35/28 ,  A61L27/00 ,  C07K14/78 ,  A61L27/50 ,  A61L27/56

Abstract: An object of the present invention is to provide a cell structure which does not contain glutaraldehyde and can form blood vessels after transplantation, and a method for producing the above-described cell structure. According to the present invention, there is provided a cell structure which contains a biocompatible macromolecular block and at least one kind of cell and has voids and in which a plurality of the biocompatible macromolecular blocks are arranged in gaps between a plurality of the cells, in which a ratio of the volume of the biocompatible macromolecular blocks with respect to the volume of the cell structure is 10% to 30%, a ratio of the volume of the cells with respect to the volume of the cell structure is 20% to 50%, and a ratio of the volume of the voids with respect to the volume of the cell structure is 35% to 60%.

公开(公告)号：US10335514B2

公开(公告)日：2019-07-02

申请号：US15472855

申请日：2017-03-29

Applicant: FUJIFILM Corporation

Inventor： Reiko Iwazawa ,  Kentaro Nakamura

IPC: A61L27/38 ,  A61K9/16 ,  A61K35/39 ,  A61K47/42 ,  A61L27/00 ,  A61K35/12 ,  A61L27/22 ,  A61L27/56

Abstract: An object is to provide a composition containing a pancreatic islet, a cell structure containing a pancreatic islet or a pancreatic islet cell, a pancreatic islet transplantation kit, a pancreatic islet transplantation treatment agent, and a hypoglycemic agent which improve at least one of glucose sensitivity or blood sugar level-reducing performance after transplantation, and to provide a composition containing a pancreatic islet, a kit containing a pancreatic islet, a pancreatic islet cell transplantation treatment agent, and a hypoglycemic agent which can improve glucose sensitivity. A composition including (A): a cell structure containing a biocompatible macromolecular block and at least one kind of cell and in which a plurality of the above-described macromolecular blocks are arranged in gaps between a plurality of the above-described cells; and (B): a pancreatic islet, and a composition containing a pancreatic islet; and a spheroid formed of at least one type of stem cell are provided.

公开(公告)号：US20180361020A1

公开(公告)日：2018-12-20

申请号：US16118754

申请日：2018-08-31

Applicant: FUJIFILM Corporation

Inventor： Kentaro Nakamura ,  Reiko Iwazawa ,  Hayato Miyoshi ,  Kazuhiro Yamaguchi ,  Hideo Fushimi

IPC: A61L27/22 ,  C12N5/00 ,  A61L27/56 ,  A61L27/58 ,  A61L27/36 ,  A61L27/38

Abstract: It is an object of the present invention to provide a cell construct for cell transplantation that does not contain a substance having cytotoxicity, such as glutaraldehyde, and suppresses the necrosis of the transplanted cells in the construct (namely, having a high cell survival rate). The present invention provides a cell construct for cell transplantation comprising biocompatible polymer blocks that do not contain glutaraldehyde and at least one type of cells, wherein a plurality of biocompatible polymer blocks are disposed in gaps among a plurality of cells, and wherein the biocompatible polymer blocks have a tap density of 10 mg/cm3 or more and 500 mg/cm3 or less, or the value of the square root of the cross-sectional area/boundary length in the two-dimensional sectional image of the polymer block is 0.01 or more and 0.13 or less.