公开(公告)号：US20180223439A1

公开(公告)日：2018-08-09

申请号：US15947746

申请日：2018-04-06

Applicant: FloDesign Sonics, Inc.

Inventor： BART LIPKENS ,  WALTER M. PRESZ, JR. ,  JASON DIONNE ,  RUI TOSTOES ,  GOUTAM GHOSHAL

IPC: C25B9/00 ,  A61L2/025 ,  C01B13/11 ,  C02F1/36 ,  C12M1/00 ,  C25B1/13

CPC classification number: C25B9/00 ,  A61L2/025 ,  C01B13/11 ,  C02F1/36 ,  C02F1/4672 ,  C02F1/78 ,  C02F2001/46138 ,  C02F2201/782 ,  C02F2209/006 ,  C02F2209/008 ,  C02F2303/04 ,  C12M47/02 ,  C12M47/04 ,  C25B1/13

Abstract: Methods for causing interaction between two sets of particles are disclosed herein. The two sets of particles are co-located in a multi-dimensional acoustic standing wave, or are co-located by acoustic streaming. This is more effective than conventional methods, for example by increasing the homogeneity of the fluid mixture containing the particles, while using reduced amounts of one particle set.

公开(公告)号：US20190211462A1

公开(公告)日：2019-07-11

申请号：US16299101

申请日：2019-03-11

Applicant: FloDesign Sonics, Inc.

Inventor： BART LIPKENS ,  Goutam Ghoshal ,  Nicholas Manzi ,  Thomas J. Kennedy, III ,  Rui Tostoes ,  Benjamin Ross-Johnsrud

IPC: C25B9/00 ,  C01B13/11 ,  C02F1/36 ,  C12M1/00 ,  C25B1/13 ,  A61L2/025

CPC classification number: C25B9/00 ,  A61L2/025 ,  C01B13/11 ,  C02F1/36 ,  C02F1/4672 ,  C02F1/78 ,  C02F2001/46138 ,  C02F2201/782 ,  C02F2209/006 ,  C02F2209/008 ,  C02F2303/04 ,  C12M47/02 ,  C25B1/13

Abstract: Methods for introducing foreign nucleic acids into cells, such as by performing transfection/transduction, using acoustic processes are disclosed herein. The foreign DNA/RNA and the cells are co-located in a multi-dimensional acoustic standing wave, or are co-located by acoustic streaming.

公开(公告)号：US20180298323A1

公开(公告)日：2018-10-18

申请号：US15947770

申请日：2018-04-06

Applicant: FloDesign Sonics, Inc.

Inventor： BART LIPKENS ,  BENJAMIN ROSS-JOHNSRUD ,  ERIK MILLER ,  MARK BROWER

IPC: C12M1/00 ,  B01D17/04

Abstract: Acoustic perfusion devices and processes for separating biomolecules from other material in a fluid mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid mixture is being drawn.