公开(公告)号：US11827581B2

公开(公告)日：2023-11-28

申请号：US17741112

申请日：2022-05-10

Applicant: Fudan University

Inventor： Fener Chen ,  Minjie Liu ,  Meifen Jiang ,  Dang Cheng ,  Chao Yu ,  Huashan Huang

IPC: C07C227/12 ,  C07C227/08 ,  B01J19/00

CPC classification number: C07C227/12 ,  B01J19/0093 ,  C07C227/08 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00889 ,  C07C227/08 ,  C07C229/22

Abstract: A full continuous-flow preparation method of L-carnitine, including: mixing chlorine gas and a diketene solution via a first micromixer followed by transportation to a first microchannel reactor for continuous chlorination and esterification reaction to obtain 4-chloroacetoacetate; feeding the 4-chloroacetoacetate and a reductase to a second micromixer and a second microchannel reactor in sequence for continuous catalytic reaction to obtain (R)-4-chloro-3-hydroxybutyrate; simultaneously transporting the (R)-4-chloro-3-hydroxybutyrate and a trimethylamine solution to a third micromixer and a third microchannel reactor for continuous substitution and hydrolysis reaction; and subjecting the reaction mixture to desalination and concentration to obtain the L-carnitine.

公开(公告)号：US11618727B2

公开(公告)日：2023-04-04

申请号：US17384747

申请日：2021-07-24

Applicant: Fudan University

Inventor： Fener Chen ,  Meifen Jiang ,  Minjie Liu ,  Dang Cheng ,  Chao Yu ,  Huashan Huang

IPC: C07C67/31 ,  B01J19/00

Abstract: This disclosure relates to organic synthesis, and more particularly to a method for preparing 3-chloro-4-oxopentyl acetate using a fully continuous-flow micro-reaction system. In this method, chlorine and an acetylbutyrolactone-containing liquid are simultaneously transported to a first micro-channel reactor for continuous chlorination to obtain α-acetyl-α-chloro-γ-butyrolactone. The reaction mixture is simultaneously transported to a micro-mixer and a second micro-channel reactor together with a mixed solution of glacial acetic acid, hydrochloric acid and water, and the continuous acylation is carried out to obtain 3-chloro-4-oxopentyl acetate. After quenched with a quenching agent, the reaction mixture was subjected to extraction and separation to obtain the 3-chloro-4-oxopentyl acetate.