公开(公告)号：US11994471B2

公开(公告)日：2024-05-28

申请号：US18159638

申请日：2023-01-25

Applicant: GEN-PROBE INCORPORATED

Inventor： Norbert Hagen ,  George Walker ,  David Combs

IPC: G01N21/64 ,  C12Q1/6806 ,  G02B6/08

CPC classification number: G01N21/6486 ,  C12Q1/6806 ,  G01N21/6452 ,  G02B6/08 ,  G01N2021/6484

Abstract: An apparatus for detecting an optical signal emission includes signal transmission fibers. Each fiber includes cores having the same spatial core arrangement at each end. The first ends are configured to be optically coupled to the signal emission sources. Each fiber is configured to transmit an optical signal between the first end and the second. The apparatus can also include a frame assembly securing the first ends of the fibers in a first spatial fiber arrangement corresponding to a spatial arrangement of the signal emission sources. The frame assembly can also secure the second ends of the fibers in a second spatial fiber arrangement different from the first spatial fiber arrangement. The apparatus can also include at least one signal detector configured to be optically coupled to the second ends of the fibers and configured to detect an optical signal emitted by each signal emission source.

公开(公告)号：US11585760B2

公开(公告)日：2023-02-21

申请号：US16633985

申请日：2018-07-25

Applicant: Gen-Probe Incorporated

Inventor： Norbert Hagen ,  George Walker, II ,  David Combs

IPC: G01N21/64 ,  C12Q1/6806 ,  G02B6/08

Abstract: An apparatus for detecting an optical signal emissions includes signal transmission fibers. Each fiber includes cores having the same spatial core arrangement at each end. The first ends are configured to be optically coupled to the signal emission sources. Each fiber is configured to transmit an optical signal between the first end and the second. The apparatus can also include a frame assembly securing the first ends of the fibers in a first spatial fiber arrangement corresponding to a spatial arrangement of the signal emission sources. The frame assembly can also secure the second ends of the fibers in a second spatial fiber arrangement different from the first spatial fiber arrangement. The apparatus can also include at least one signal detector configured to be optically coupled to the second ends of the fibers, and configured to detect an optical signal emitted by each signal emission source.

公开(公告)号：US20220291454A1

公开(公告)日：2022-09-15

申请号：US17830115

申请日：2022-06-01

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: G02B6/36 ,  G02B6/06 ,  G02B6/08 ,  G01N21/25 ,  G01N21/64 ,  G02B6/42

Abstract: A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature. Signal emissions of receptacles subject to the second thermal cycling process are synchronized with specific temperatures of the second thermal cycling process by comparing time stamps of the second time/signal emission data set for each receptacle with the time stamps of the second time/temperature data set that correspond with the specific temperature.