公开(公告)号：US20130116192A1

公开(公告)日：2013-05-09

申请号：US13638422

申请日：2011-03-30

Applicant: Gosbert Weth

Inventor： Gosbert Weth

IPC: A61K38/05 ,  C07K5/06

CPC classification number: C07K5/06026 ,  Y10T436/175383

Abstract: N-(aminoacyl)-amino compound, represented by the following formula Wherein R1 denotes hydrogen, low alkyl or carbonyl, and N1 denotes an NH group and R2 denotes hydrogen or low alkylphenyl or aralkyl or imidazoalkyl or indolylalkyl, R1 and R2 together may complete a pyrrolidine or piperidine or thiazolidine ring and R3 denotes hydrogen or methyl or low alkyl and R4 denotes hydrogen or alkyl or the group remaining on exclusion of R4 from the formula and Z is a straight chain or branched alkylene, which may contain up to 3 carbon atoms. and R5 is nitrogen or sulphur or oxygen or salts thereof and ester compounds, characterised in that A is an ester or amino acid or alternatively sodium or a potassium salt of arginate and/or of ornithate and/or of aspharaginate.

Abstract translation: 由下式表示的N-（氨酰基） - 氨基化合物，其中R1表示氢，低级烷基或羰基，N1表示NH基团，R2表示氢或低级烷基苯基或芳烷基或咪唑烷基或吲哚基烷基，R1和R2可以完成 吡咯烷或哌啶或噻唑烷环，R 3表示氢或甲基或低级烷基，R 4表示氢或烷基或在下式排除R 4时残留的基团，Z是直链或支链亚烷基，其可含有至多3个碳 原子 并且R 5是氮或硫或氧或其盐和酯化合物，其特征在于A是精氨酸盐和/或鸟氨酸盐和/或芳香酸盐的酯或氨基酸或替代物的钠盐或钾盐。

公开(公告)号：US6068596A

公开(公告)日：2000-05-30

申请号：US946721

申请日：1997-10-08

Applicant: Gosbert Weth ,  Gunter Wilhelm

Inventor： Gosbert Weth ,  Gunter Wilhelm

IPC: A61N1/34 ,  A61B17/225 ,  A61H9/00 ,  A61H23/00 ,  A61H23/02 ,  A61H39/00 ,  A61H39/04 ,  A61M21/00 ,  A61N1/18 ,  A61N1/36 ,  A61N1/362 ,  A61N5/02 ,  A61N7/00

CPC classification number: A61H9/00 ,  A61H23/008 ,  A61H23/0218 ,  A61H9/0071 ,  A61N1/3621 ,  A61N5/02 ,  A61N7/00 ,  A61H2023/002 ,  A61H39/04

Abstract: In an apparatus and a method for pain therapy and/or for influencing the autonomic nervous system, at least one pulse-like wave is conducted onto a neurally sensitive region with an apparatus, namely a source of pulse-like waves the region participating in the conduction with respect to the pain or with respect to the region of the autonomic nervous system to be influenced.

Abstract translation: 在用于疼痛治疗和/或影响自主神经系统的装置和方法中，至少一个脉冲状波被传导到神经敏感区域上，该设备是脉冲状波源，参与该区域的区域 相对于疼痛的传导或对自主神经系统的区域的影响。

公开(公告)号：US20120022374A1

公开(公告)日：2012-01-26

申请号：US13124629

申请日：2008-10-18

Applicant: Gosbert Weth

Inventor： Gosbert Weth

IPC: A61H1/00 ,  A61B8/00

CPC classification number: G10K15/06 ,  A61H23/008 ,  A61H23/0218 ,  A61H39/04 ,  A61H2201/10 ,  A61H2201/1654 ,  A61N2/00

Abstract: A pulse wave generator includes a housing having a pressure field generator from which individually controllable pressure pulses can be emitted, a pressure pulse focusing unit by which the pressure pulses can be focused at the focusing point in, or on, a body of a living being, a pressure coupler, from which the pressure pulses can be transmitted to the body, a controller for the intensity and point in time of each pressure pulse, at least one further field generator being integrated by which the individually controllable field pulses can be generated in the focusing point and the intensity and time of each pulse can be controlled.

Abstract translation: 脉搏波发生器包括具有压力场发生器的壳体，从该压力脉冲发生器可单独控制压力脉冲;压力脉冲聚焦单元，通过该压力脉冲聚焦单元，压力脉冲可以聚焦于生物体内或其上的聚焦点 压力耦合器，压力脉冲可以从该压力传递到身体，用于每个压力脉冲的强度和时间点的控制器，至少一个另外的场发生器被积分，通过该另外的场发生器可以在 可以控制每个脉冲的聚焦点和强度和时间。

公开(公告)号：US5727556A

公开(公告)日：1998-03-17

申请号：US500950

申请日：1995-08-08

Applicant: Gosbert Weth ,  Gunter Wilhelm

Inventor： Gosbert Weth ,  Gunter Wilhelm

IPC: A61N1/34 ,  A61B17/225 ,  A61H9/00 ,  A61H23/00 ,  A61H23/02 ,  A61H39/00 ,  A61H39/04 ,  A61M21/00 ,  A61N1/18 ,  A61N1/36 ,  A61N1/362 ,  A61N5/02 ,  A61N7/00

CPC classification number: A61H9/00 ,  A61H23/008 ,  A61H23/0218 ,  A61H9/0071 ,  A61N1/3621 ,  A61N5/02 ,  A61N7/00 ,  A61H2023/002 ,  A61H39/04

Abstract: In an apparatus and a method for pain therapy and/or for influencing the autonomic nervous system, at least one pulse-like wave is conducted onto a neurally sensitive region with an apparatus, namely a source of pulse-like waves the region participating in the conduction with respect to the pain or with respect to the region of the autonomic nervous system to be influenced.

Abstract translation: PCT No.PCT / DE94 / 00133 Sec。 371日期：1995年8月8日 102（e）日期1995年8月8日PCT 1994年2月9日PCT PCT。 第WO94 / 17771号公报 日期1994年8月18日在用于疼痛治疗和/或影响自主神经系统的装置和方法中，至少一个脉冲状波通过装置即脉冲状波的来源进入神经敏感区域 该区域参与对疼痛的传导或对自主神经系统的区域的影响。

公开(公告)号：US5589499A

公开(公告)日：1996-12-31

申请号：US339423

申请日：1994-11-14

Applicant: Gosbert Weth

Inventor： Gosbert Weth

IPC: A61K31/401 ,  A61K31/40

CPC classification number: A61K31/401

Abstract: The invention deals with the use of N-(aminoacyl)-amino acids of Formula (I), especially anapril, (2 R, 4 R)-2-(2-hydroxy-phenyl)-3-(3-aminopropionyl)-4-thiazolidine carboxylic acid, and 1-[(2 S)-3-amino-4-methyl-propionyl]-2-proline as dopaminergic active ingredients for increasing central or peripheral blood flow disorders.

Abstract translation: 本发明涉及式（I）的N-（氨基酰基） - 氨基酸，特别是阿普利，（2R，4R）-2-（2-羟基 - 苯基）-3-（3-氨基丙酰基） - 4-噻唑烷羧酸和1 - [（2S）-3-氨基-4-甲基 - 丙酰基] -2-脯氨酸作为增加中枢或外周血流紊乱的多巴胺能活性成分。