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公开(公告)号：US09658237B2
公开(公告)日：2017-05-23
申请号：US14415300
申请日：2013-06-13
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Tomonori Mimura , Akihisa Makino , Manabu Ando , Sakuichiro Adachi
IPC: G01N35/02 , G01N21/31 , G01N21/13 , G01N21/49 , G01N21/51 , G01N21/53 , G01N21/59 , G01N35/00 , G01N21/27 , G01N35/04
CPC classification number: G01N35/025 , G01N21/13 , G01N21/272 , G01N21/31 , G01N21/49 , G01N21/51 , G01N21/532 , G01N21/59 , G01N35/00613 , G01N2035/0453 , G01N2201/02 , G01N2201/062
Abstract: There is provided an automatic analyzer including: a sample pipetting mechanism 7, reagent pipetting mechanisms 12A and 12B, mixing mechanisms 33A and 33B, a scattered light photometer 40, and an absorption photometer 41 all located on a transfer path of reaction cells 2 arranged circumferentially on a disk-shaped reaction disk 1, the reaction cells 2 being transferred in the circumferential direction by rotation of the reaction disk 1. Scattered light intensity and absorbance are controlled to be measured by causing the reaction cells 2 to move past a scattered light detection position and a transmitted light detection position in the same process of movement, the two positions being established beforehand on the transfer path. This makes it possible to suppress the effects on measurement results of the difference in time between scattered light measurement and absorbance measurement thereby improving measurement accuracy.
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公开(公告)号：US20150198525A1
公开(公告)日：2015-07-16
申请号：US14670861
申请日：2015-03-27
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
IPC: G01N21/51
CPC classification number: G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
Abstract: To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
Abstract translation: 适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。 为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。 为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。
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公开(公告)号：US10113962B2
公开(公告)日：2018-10-30
申请号：US14670861
申请日：2015-03-27
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
Abstract: To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
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公开(公告)号：US09023282B2
公开(公告)日：2015-05-05
申请号：US14484384
申请日：2014-09-12
Applicant: Hitachi High-Technologies Corporation
Inventor： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
CPC classification number: G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
Abstract: To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
Abstract translation: 适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。 为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。 为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。
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公开(公告)号：US20140377853A1
公开(公告)日：2014-12-25
申请号：US14484384
申请日：2014-09-12
Applicant: Hitachi High-Technologies Corporation
Inventor： Sakuichiro Adachi , Muneo Maeshima , Isao Yamazaki , Tomonori Mimura
IPC: G01N21/51
CPC classification number: G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
Abstract: To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
Abstract translation: 适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。 为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。 为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。
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Patent Agency Ranking
公开(公告)号：US09335335B2
公开(公告)日：2016-05-10
申请号：US14422278
申请日：2013-07-11
Applicant: Hitachi High-Technologies Corporation
Inventor： Tomonori Mimura , Kumiko Kamihara , Isao Yamazaki , Hideto Tamezane
CPC classification number: G01N35/00623 , G01N35/00871 , G01N35/1016 , G01N2035/00891 , G01N2035/1018 , Y10T436/11
Abstract: Provided is an automatic analyzer capable of detecting not only clogging and air suction of the dispensation probe but also a decrease in the dispensation quantity caused by a bubble film, air bubbles or a highly viscous sample. Each of a sample/reagent suction operation time and a sample/reagent discharge operation time of a probe is segmented into multiple time sections. For each of the time sections determined by the segmentation, a parameter is calculated by applying a detected pressure waveform to an approximation formula. For each of the time section, the presence/absence of a dispensation abnormality is judged by comparing the calculated parameter with a parameter in cases of normal dispensation. An automatic analyzer capable of judging the presence/absence of an abnormality specific to each time section and making abnormality judgments difficult for conventional techniques can be realized.
Abstract translation: 本发明提供一种能够不仅检测分注用探针的堵塞和吸气的自动分析装置，还能够检测由气泡膜，气泡或高粘度样品引起的分配量的降低。 探针的样品/试剂抽吸操作时间和样品/试剂放电操作时间分别被分割成多个时间段。 对于通过分割确定的每个时间段，通过将检测到的压力波形应用于近似公式来计算参数。 对于每个时间段，通过将计算出的参数与正常分配情况下的参数进行比较来判断分配异常的存在/不存在。 可以实现能够判断各时间段特有的异常的有无的自动分析装置，并且可以实现常规技术难以进行异常判断。
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公开(公告)号：US20150185242A1
公开(公告)日：2015-07-02
申请号：US14415300
申请日：2013-06-13
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Tomonori Mimura , Akihisa Makino , Manabu Ando , Sakuichiro Adachi
CPC classification number: G01N35/025 , G01N21/13 , G01N21/272 , G01N21/31 , G01N21/49 , G01N21/51 , G01N21/532 , G01N21/59 , G01N35/00613 , G01N2035/0453 , G01N2201/02 , G01N2201/062
Abstract: There is provided an automatic analyzer including: a sample pipetting mechanism 7, reagent pipetting mechanisms 12A and 12B, mixing mechanisms 33A and 33B, a scattered light photometer 40, and an absorption photometer 41 all located on a transfer path of reaction cells 2 arranged circumferentially on a disk-shaped reaction disk 1, the reaction cells 2 being transferred in the circumferential direction by rotation of the reaction disk 1. Scattered light intensity and absorbance are controlled to be measured by causing the reaction cells 2 to move past a scattered light detection position and a transmitted light detection position in the same process of movement, the two positions being established beforehand on the transfer path. This makes it possible to suppress the effects on measurement results of the difference in time between scattered light measurement and absorbance measurement thereby improving measurement accuracy.
Abstract translation: 提供了一种自动分析装置，其包括：样本移液机构7，试剂吸移机构12A和12B，混合机构33A和33B，散射光光度计40和吸收光度计41，其全部位于沿周向布置的反应单元2的传送路径上 在圆盘状的反应盘1上，反应池2通过反应盘1的旋转沿圆周方向转移。通过使反应池2移动经过散射光检测来控制分散的光强度和吸光度 位置和在相同移动过程中的透射光检测位置，两个位置预先在传送路径上建立。 这样可以抑制散射光测量和吸光度测量之间的时间差的测量结果的影响，从而提高测量精度。
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公开(公告)号：US09291634B2
公开(公告)日：2016-03-22
申请号：US14171790
申请日：2014-02-04
Applicant: Hitachi High-Technologies Corporation
Inventor： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
CPC classification number: G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
Abstract: Chemical analysis apparatus for inserting a sample serving as an analyzable substance and a reagent into a reaction container and agitating by irradiating sound waves to the reaction container, the chemical analysis apparatus including: a piezoelectric element generating sound waves; and a driver for driving the piezoelectric element, and including: a wave form producing device for producing an oscillation waveform having a fundamental frequency of the sound waves to be irradiated; an auxiliary waveform producing device for producing an oscillation wave form having a frequency lower than that of the oscillation waveform; a multiplying circuit creating a multiplied waveform between the waveform and the wave form; and, a power amplifier for power-amplifying the multiplied waveform, wherein it is intermittently irradiated with the sound wave in the reaction container, and further, the wave form producing device has a function capable of frequency-modulation with a prescribed frequency width.
Abstract translation: 用于将用作可分析物质和试剂的样品插入反应容器并通过向反应容器照射声波进行搅拌的化学分析装置，所述化学分析装置包括：产生声波的压电元件; 以及用于驱动压电元件的驱动器，并且包括：波形产生装置，用于产生具有待照射的声波的基频的振荡波形; 用于产生频率低于振荡波形的振荡波形的辅助波形产生装置; 在波形和波形之间产生相乘波形的乘法电路; 以及用于对乘法波形进行功率放大的功率放大器，其中它被反应容器中的声波间歇地照射，此外，波形产生装置具有能够以规定频率宽度进行频率调制的功能。
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公开(公告)号：US10168345B2
公开(公告)日：2019-01-01
申请号：US14411304
申请日：2013-05-30
Applicant: Hitachi High-Technologies Corporation
Inventor： Akiko Yokokawa , Tomonori Mimura , Sakuichiro Adachi
Abstract: An automatic analysis apparatus capable of improving detection sensitivity is provided. An optimum photometer between a light-scattering photometer and an absorptiometer based on a concentration range may be decided. A standard solution is measured multiple times at a normal calibration and a calibration curve is created. Calibration curves are individually created for an absorptiometer and a light-scattering photometer from the minimum and maximum measured values of the concentrations of each standard solution. The upper and lower limits of a standard solution concentration are computed from the minimum/maximum calibration curves. Sensitivity may be computed by using calibration parameters. Whether to use a concentration by absorption or a concentration by scattered light is decided based on the computed sensitivity. The computed sensitivities are compared between the concentration by absorption and the concentration by scattered light, and the use of the concentration of a higher sensitivity is decided.
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公开(公告)号：US20150219680A1
公开(公告)日：2015-08-06
申请号：US14422278
申请日：2013-07-11
Applicant: Hitachi High-Technologies Corporation
Inventor： Tomonori Mimura , Kumiko Kamihara , Isao Yamazaki , Hideto Tamezane
CPC classification number: G01N35/00623 , G01N35/00871 , G01N35/1016 , G01N2035/00891 , G01N2035/1018 , Y10T436/11
Abstract: Provided is an automatic analyzer capable of detecting not only clogging and air suction of the dispensation probe but also a decrease in the dispensation quantity caused by a bubble film, air bubbles or a highly viscous sample. Each of a sample/reagent suction operation time and a sample/reagent discharge operation time of a probe is segmented into multiple time sections. For each of the time sections determined by the segmentation, a parameter is calculated by applying a detected pressure waveform to an approximation formula. For each of the time section, the presence/absence of a dispensation abnormality is judged by comparing the calculated parameter with a parameter in cases of normal dispensation. An automatic analyzer capable of judging the presence/absence of an abnormality specific to each time section and making abnormality judgments difficult for conventional techniques can be realized.
Abstract translation: 本发明提供一种能够不仅检测分注用探针的堵塞和吸气的自动分析装置，还能够检测由气泡膜，气泡或高粘度样品引起的分配量的降低。 探针的样品/试剂抽吸操作时间和样品/试剂放电操作时间分别被分割成多个时间段。 对于通过分割确定的每个时间段，通过将检测到的压力波形应用于近似公式来计算参数。 对于每个时间段，通过将计算出的参数与正常分配情况下的参数进行比较来判断分配异常的存在/不存在。 可以实现能够判断各时间段特有的异常的有无的自动分析装置，并且可以实现常规技术难以进行异常判断。
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